管理员 2011-09-06 10:37 IP:重庆
  Enriching Low-Abundance Serum & Plasma Proteins   AWARD: $30,000 USD | DEADLINE: 10/01/11 | ACTIVE SOLVERS: 254 | POSTED: 8/01/11   Source: InnoCentive Challenge ID: 9932714 Type: Theoretical-licensing   Detailed Description & Requirements   Concentrations of proteins in serum and plasma span up to 10 orders of magnitude – e.g. from serum albumin (50 mg/ml) to some cytokines and chemokines (<5 pg/ml)   Protein molecules most useful to researchers exist at levels that are approximately at or below the 10,000 pg/ml range. Detection and quantification of these low-abundance proteins is obscured by the presence of high abundance proteins. Current methods for reducing the concentration of high-abundance proteins are either inefficient, targeted at certain proteins, or introduce bias and other artifacts.   The Seeker is looking to identify novel methods to reliably reduce or eliminate high abundance proteins so that detection of protein analytes present at the 1-10 ng/ml scale or lower may be accurately detected.   The Seeker envisages that a sample preparation techniques may be the most likely route to a solution. However, alternative approaches are also welcomed. The Seeker is highly experienced in sample preparation technologies for reduction of high-abundance proteins & is not interested in simple proposals of commercially available, or published, technologies and techniques.   The Seeker is aware of the following ‘sample enrichment’ technologies for reducing the concentration of high abundance proteins from serum & plasma. The techniques are listed together with their limitations for the Seeker:   Immunoaffinity depletions– depletions are extremely specific to the antigens the antibodies target. Commercially available kits commonly deplete 6-20 high abundance proteins with more than 90% efficiency. Although this enables detection of more low-abundance proteins, the column-based process induces some bias in low-abundance protein   [更多]
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ku59337187 2013-03-31 19:37 IP:南阳
我想加工一些颗粒,需要自动分量打包的设备   [更多]
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cuidan1211 2013-06-16 19:40 IP:北京
用于药品质量分析检测,分析西药成分,意向购买岛津的,要求全套设备及系统软件,并且能够自动进样。   [更多]
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wuji 2013-07-31 08:45 IP:重庆
技术求购内容: 1.氧杂环丁烷(oxetane),氮杂环丁烷(azetidine),硫杂环丁烷(thietane)及其螺环化合物的合 成及工艺放大研究; 2.其他新药物砌块及特殊药物中间体的合成和工艺放大; 3.向科瑞提供上述的中间体   [更多]
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gonggong 2013-08-09 13:41 IP:重庆
【技术主题】5-氟胞嘧啶及其他原料药和中间体 【详细说明】工艺成熟,适于大生产,成本和质量具备优势。拒绝不成熟研发阶段工艺,不希望无诚意的合作。   [更多]
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gonggong 2013-08-26 10:57 IP:重庆
自1775年抽水马桶被发明以来就没有经历什么大的变化,现在,技术创新将要掀起一场针对马桶的革命。为此,比尔及梅琳?盖茨基金会“悬赏”500万美元在中国寻找“下一代马桶”。 比尔及梅琳?盖茨基金会资助的“厕所创新大赛—中国区”活动于22日在京正式启动,盖茨基金会计划从即日起到2015年,资助中国的科研机构、企业、发明家等各类创新力量,以促进卫生、环保、舒适、廉价的“下一代厕所”尽早服务于全世界。 “我们人类已经把人送上月球,但却还有25亿人缺乏满足基本安全、卫生需求的厕所,全球每年因人类排泄物直接导致150万儿童死亡。”盖茨基金会高级项目官邝东来说。截至目前,盖茨基金会已经资助了包括非洲、亚洲、欧洲以及北美在内的16个科研机构进行“下一代厕所”的各种技术研发,而中国区活动,是大赛首次为某一个单独国家专门开设的项目。 盖茨基金会认为,“下一代马桶”必须满足四个基本条件。 一、环保:它可以去除人类排泄物中的病原体,并重新利用其中的有效资源; 二、节能:它不需要外接水源、电源以及排水管道系统; 三、廉价:每人每天使用它的综合成本少于5美分; 四、舒适:美观、无异味,无论在发达国家还是发展中国家,人们都喜欢使用它。   [更多]
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wuji 2013-08-29 16:09 IP:重庆
菌菇粉碎至细小颗粒,经提取后,造成后期料液分离效率低,若您有合适的分离技术与设备,请与我联系   [更多]
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wuji 2013-09-04 10:18 IP:重庆
产品名称:去氢表雄酮; 脱氢表雄甾酮 要求:有资质,有检查报告   [更多]
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wuji 2013-09-04 11:21 IP:重庆
求高纯磷钨酸清洁合成技术 要求:综合得率: ≥85% 不溶物: ≤ 0.020% 氯化物(Cl-): ≤ 0.010%   [更多]
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avtlethy 2013-09-11 12:44 IP:上海
可用作医药中间体,除对分子量、PH等有常规要求外,对二醇含量、重金属等也要符合合成、药用的要求。 Specifications appearance: white to pale yallowish flaks PH: 4.5-7.5 average molecular weight: 1800-2200 diol contet: not more than 1% heavy metals: not more than 5ppm residue on ignition: not more than 0.1%   [更多]
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