管理员 2011-09-06 10:37 IP:重庆
  Enriching Low-Abundance Serum & Plasma Proteins   AWARD: $30,000 USD | DEADLINE: 10/01/11 | ACTIVE SOLVERS: 254 | POSTED: 8/01/11   Source: InnoCentive Challenge ID: 9932714 Type: Theoretical-licensing   Detailed Description & Requirements   Concentrations of proteins in serum and plasma span up to 10 orders of magnitude – e.g. from serum albumin (50 mg/ml) to some cytokines and chemokines (<5 pg/ml)   Protein molecules most useful to researchers exist at levels that are approximately at or below the 10,000 pg/ml range. Detection and quantification of these low-abundance proteins is obscured by the presence of high abundance proteins. Current methods for reducing the concentration of high-abundance proteins are either inefficient, targeted at certain proteins, or introduce bias and other artifacts.   The Seeker is looking to identify novel methods to reliably reduce or eliminate high abundance proteins so that detection of protein analytes present at the 1-10 ng/ml scale or lower may be accurately detected.   The Seeker envisages that a sample preparation techniques may be the most likely route to a solution. However, alternative approaches are also welcomed. The Seeker is highly experienced in sample preparation technologies for reduction of high-abundance proteins & is not interested in simple proposals of commercially available, or published, technologies and techniques.   The Seeker is aware of the following ‘sample enrichment’ technologies for reducing the concentration of high abundance proteins from serum & plasma. The techniques are listed together with their limitations for the Seeker:   Immunoaffinity depletions– depletions are extremely specific to the antigens the antibodies target. Commercially available kits commonly deplete 6-20 high abundance proteins with more than 90% efficiency. Although this enables detection of more low-abundance proteins, the column-based process induces some bias in low-abundance protein   [更多]
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¥20000.00
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wuji 2013-07-31 08:45 IP:重庆
技术求购内容: 1.氧杂环丁烷(oxetane),氮杂环丁烷(azetidine),硫杂环丁烷(thietane)及其螺环化合物的合 成及工艺放大研究; 2.其他新药物砌块及特殊药物中间体的合成和工艺放大; 3.向科瑞提供上述的中间体   [更多]
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¥0.00
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wuji 2013-09-04 11:21 IP:重庆
求高纯磷钨酸清洁合成技术 要求:综合得率: ≥85% 不溶物: ≤ 0.020% 氯化物(Cl-): ≤ 0.010%   [更多]
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¥0.00
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avtlethy 2013-09-11 12:44 IP:上海
可用作医药中间体,除对分子量、PH等有常规要求外,对二醇含量、重金属等也要符合合成、药用的要求。 Specifications appearance: white to pale yallowish flaks PH: 4.5-7.5 average molecular weight: 1800-2200 diol contet: not more than 1% heavy metals: not more than 5ppm residue on ignition: not more than 0.1%   [更多]
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¥0.00
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Singer 2014-05-12 12:08 IP:广州
需要10mg 纯度要求95%以上 提供物质的COA 液相图谱、质谱图谱、核磁共振图谱   [更多]
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¥10.00
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mixian 2014-11-14 11:17 IP:重庆
需要100g,有可以提供的么?图见附件。   [更多]
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¥0.00
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chemicalsales 2014-11-22 11:50 IP:南京
求购三(乙基-3-氧代丁氧基-O1’,O3)-铝 100克,cas:15306-17-9   [更多]
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¥0.00
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mixian 2014-11-26 16:58 IP:重庆
寻产品CAS:73978-41-3 2,4-二氨基-6-羟甲基蝶啶盐酸盐 1KG 谁家可以提供Q我啊 图见附件   [更多]
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¥0.00
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mixian 2014-11-27 15:41 IP:重庆
求购CAS:796967-16-3 利尼伐尼 30G 谁可以提供?图见附件   [更多]
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¥0.00
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chemicalsales 2014-12-02 20:49 IP:南京
求购三(乙基-3-氧代丁氧基-O1’,O3)-铝 1kg克,cas:15306-17-9   [更多]
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¥1.00
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