当前位置：   首页 > 需求大厅

单人中标 赏金分配： $ 50,000 截止日期：计2015年1月12日 已有提案：57 件 发布时间：2014年11月6日 已选0个，还需要1个。 具体要求： 与年龄相关的黄斑变性（AMD）是造成50岁以上人的视力丧失的主要原因。黄斑变性会造成视网膜的中央点损害，并模糊，最后会使一个或两个眼睛发展到失明。虽然AMD已有少量模型存在，但并没有充分阐明疾病的病理，而且也不适合于彻底深入地筛选和开发药物。年龄相关性黄斑变性（AMD）被认为是由遗传和环境因素来触发一种复杂而且异质性疾病。正如它的名字所示的，随着年龄的增长AMD发病率增加，据估计，在美国，大约有800万55周岁以上的人具有中期或后期的疾病。 AMD出现的第一症状为黄斑色素的改变和被称为玻璃疣的视网膜下沉积物。疾病进一步发展可能导致视网膜色素上皮（RPE）细胞和光感受器细胞或新血管的血管渗透，出血和疤痕。光感受器细胞和视网膜色素上皮细胞之间的相互作用对于正常的视力功能是必不可少的。这一悬赏只需要一个书面建议。 以下几条信息必须同时满足: 1. 必须在2015年1月12日下午11时59分（美国东部时间）收到，逾期的投标概不受理。只需要提案人一个书面建议提交。解决方领取奖金的同时，必须将其独有的知识产权（IP）的权利转让给举办方。 2.这个悬赏任务是必须寻找一种新的，临床前模型，描述光感受器细胞和视网膜色素上皮细胞之间的相互作用，在长期生理分化中对视力的影响，以方便对最近出现的新兴疗法进行疗效评价。 3、在这个网站投稿：Preclinical Models of Age-Related Macular Degeneration | InnoCentive Challenge https://www.innocentive.com/ar/challenge/9933641   [更多]

基因治疗的概念出现在几十年前,当研究人员推测,人类疾病可以通过精确使用一种技术引入外来DNA来解决遗传缺陷和疾病症状。近年来，基因治疗的进步已经涉足治疗遗传疾病，癌症，神经退行性疾病等各领域。遗传性疾病如色素性视网膜炎等少数眼部疾病的基因也可以如此治疗。公司征集一种在人类眼部组织定性和定量(半)测量体内基因表达的方法。 具体如下https://www.innocentive.com/ar/challenge/9933643 The concept of gene therapy arose decades ago, when researchers postulated that human diseases could be treated by using a technique to introduce foreign DNA to correct genetic defects and disease phenotypes. In recent years, advances in gene therapy have been documented in the treatment of genetic disorders, cancer, and neurodegenerative diseases. Inherited diseases such as retinitis pigmentosa are among a handful of ocular diseases that are amenable to gene therapy. The Seeker desires solutions that will both qualitatively and (semi-) quantitatively measure in vivo gene expression in human ocular tissues. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933643 Challenge Overview The number of clinical trials for gene therapy to treat ocular disorders is on the rise. Inherited diseases such as retinitis pigmentosa among others are thought to be good candidates for targeted treatment. Currently, there is no method in humans to determine the level or geographic location of transgene expression following administration of gene therapy for diseases of the eye, specifically the retina. The Seeker desires solutions that will both qualitatively and (semi-) quantitatively measure in vivo gene expression in human ocular tissues. Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on June 20, 2015. Late submissions will not be considered. This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker. To receive an award, Solvers will not be required to transfer their exclusive IP rights to the Seeker. Instead, Solvers will grant to the Seeker a   [更多]

求购药品数据库 以sql脚本交付。具体金额可以协商。所需字段名：商品名通用名包装规格包装单位是否处方药批准文号剂型药品分类厂家名称厂家联系电话生产地址封面图片包装图片详情图片用法用量用药频率说明书图片药品名称成份性状功能主治适应症规格用法用量不良反应禁忌注意事项药物相互作用贮藏包装有效期执行标准   [更多]

控释衣膜溶液中的丙酮回收装置： 我公司生产生产的参透泵控释片多以醋酸纤维素为控释衣膜，醋酸纤维素的包衣溶液是丙酮，丙酮的沸点较低，在包衣的过程丙酮挥发难以回收。请设计并提供套生产可行的丙酮回收装置。   [更多]

糖尿病术后不愈合，四肢血液不流通功能缺失修复。国内独家，寻求敢兴趣药厂合作。   [更多]

寻找一种载体某些细胞或分子如蛋白质，DNA，RNA，和microRNA，用这些载体来制备高选择性的靶向药物，给药的方法是让药物化合物给药和输送到身体的病灶而达到治疗效果。具体的要求请看下面链接：https://www.innocentive.com/ar/challenge/9933675 AWARD: $30,000 USD | DEADLINE: 2/17/15 | ACTIVE SOLVERS: 108 | POSTED: 1/16/15 Exosomes are membrane-bound vesicles that are produced by many, if not all cell types. Exosomes are able to selectively target certain cells and deliver molecules such as proteins, DNA, RNA, and microRNA. These vesicles are thought to have great potential for targeted drug delivery. The Seeker desires innovative methods for exosome drug loading without significant disruption of the membrane components and properties of the exosome. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933675 Challenge Overview Drug delivery is the method by which pharmaceutical compounds are administered and transported in the body to achieve therapeutic efficacy. Recently, exosomes have been identified as a novel method to deliver drugs in a targeted manner and their potential is derived from natural components such as specific proteins/lipids contained in the membrane of exosomes. Successful delivery of substantial amounts of therapeutic drugs using exosomes is critically dependent on a highly efficient and broadly applicable methodology for loading exosomes with the therapeutic agent, however at present no such technology is available. The Seeker is looking for one or more technologies that will facilitate exosome drug loading without significant disruption of the membrane components and properties of the exosome.   [更多]

静脉注射的优点就是快速静脉注射药物的分布在整个身体。通常,这些药物总是快速代谢，快速排出，导致短期的临床疗效。大家可以从微丸持续释放显效得皮启发。具体看链接：https://www.innocentive.com/ar/challenge/9933723 Intravenous delivery allows for the rapid distribution of injected drugs from the veins throughout the entire body. Oftentimes, these drugs are quickly metabolized and excreted resulting in short durations of clinical efficacy. Certain therapies may benefit from a bolus followed by sustained release. The Seeker wishes to identify a technology to sustain the delivery of a human high dose intravenous drug from a single injection administered over a period of 15 to 30 minutes. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933723 Challenge Overview An intravenous sustained drug delivery technology is desired for a high dose drug that needs to be delivered over 8 to 10 hours. This intravenous sustained release delivery technology would allow a bolus of drug (approximately 40 to 60%) to be delivered quickly upon intravenous administration followed by the remaining dose (60 to 40%) delivered in a near zero order fashion from this intravenous administration over an 8 to 10 hour interval. This drug delivery technology needs to use materials that are already recognized as safe or can be easily qualified for parenteral administration in humans. This drug delivery technology should present no encumbrance to nurses administering the drug in a hospital setting. This technology should be amenable to delivering about 2 grams of a drug with an aqueous solubility of approximately 0.75 grams in 50 mL at 25°C and approximately 1 gram in 50 mL at 37°C during the 8 to 10 hour interval. Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on March 21, 2015. Late submissions will not be considered. This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the   [更多]

单人中标 赏金分配： $ 30,000 截止日期：2015年1月5日 已有提案：104件 发布时间：14年11月3日 已选0个，还需要1个。 具体要求：研究人员需要一种理论和数学模型来描述已知药物分子和药物性质来预测在水溶媒中药片的溶出过程。这一悬赏只需要一个书面建议。 以下几条信息必须同时满足: 1. 必须在2015年1月5日下午11时59分（美国东部时间）收到，逾期的投标概不受理。只需要提案人一个书面建议提交。解决方领取奖金的同时，必须将其独有的知识产权（IP）的权利转让给举办方。 2.这个悬赏任务是必须寻找一种理论和数学模型来描述已知药物分子和药物性质来预测在水溶媒中药片的溶出过程。而这种药物的晶形、分子结构、活性和非活性成份的重量比、粒径、水溶液的PH等等都是已知并且固定的。 3、投稿在此网站：Multi-Scale Modeling of Tablet Dissolution | InnoCentive Challenge https://www.innocentive.com/ar/challenge/9933558   [更多]

本公司需要拉米夫定和齐多夫定的大生产工艺，有意向者请联系   [更多]

　　要求 　　1.不得侵犯他人专利，如有侵犯，提供者承担损失 　　2.要求有详细技术参数，不能只是一个合成路线 　　3.要求生产路线，成品率不得比现有公开合成方法低 　　4.要求为中试生产工艺   [更多]