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实验室拟邀请4位研究人员进行他们的研究项目。研究地点是在位于西班牙的葛兰素史克公司的药物开发园。研究人员的生活费，旅游资金，住宿费和研究所花的耗材成本皆由实验室承担。4个研究项目，每一个都有16万美元的预算。任务要求：需要有疟疾病，肺结核病和动质体疾病(南美锥虫病，利什曼病，昏睡病)等领域的开放性的研究。这项挑战的优胜者请直接联系实验室，以便根据他们的反馈和指导，做出更全面的考虑。这是一项寻找合作伙伴的任务，要求提交一份书面企划书以做评估。 Tres Cantos Open Lab Foundation: Proposals for Neglected Diseases Research TAGS: Developing Countries, Requests for Partners and Suppliers, Life Sciences, Food/Agriculture, Nature, Global Health, Computer Science/Information Technology, Chemistry, Physical Sciences, Public Good, eRFP AWARD: varies | DEADLINE: 10/29/12 | ACTIVE SOLVERS: 92 | POSTED: 9/17/12 The Tres Cantos Open Lab Foundation intends to invite up to 4 Solvers to conduct their research projects using the facilities and resources of GlaxoSmithKline’s Tres Cantos Medicines Development Campus in Spain. Researcher subsistence, travel, accommodation & consumable costs can be covered by the Tres Cantos Open Lab Foundation. Four research projects are budgeted for, each having a maximum funding of $160,000. Proposals for groundbreaking research in the areas of malarial disease, tuberculosis and kinetoplastid diseases (Chagas Disease, Leishmaniasis or Sleeping Sickness) are required. The winners of this challenge will be contacted directly by the Tres Cantos Open Lab Foundation in order to make more comprehensive proposals based on their feedback and guidance. This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by the Seeker with a goal of establishing a collaborative partnership. Source: InnoCentive Challenge ID: 9933167 Challenge Overview Are you a researcher who would like to spend from 6 to 24 months at the world class facilities of the open lab at GSK’s Tres Cantos Medicines Development Campus in Spain carrying out research that will positively impact the lives of people in the developing world? Funding for up to 4 research projects totaling up to $160,000   [更多]

“科技每年都会见证一些神奇的真理和制造出令人眼花缭乱的东西,如吴雨霏穆利斯《创新的聚合酶链式反应》。 不幸的是，他们中的大多数被淘汰出局。而聚合酶链式反应则预示着基因组的革命. 这是一项关于思维的挑战，这项任务要求挑战者来概述制药行业需要采取哪些创新，来适应这优胜劣汰的游戏规则。挑战者不需要发表明确的解决方案，你只需要清楚的描述已经存在的，可能会成为下一个制药趋势的大事。这将有助于制药行业寻找明天的药物，生产新药。 What Disruptive Innovations Does Pharma Need To Discover Tomorrow’s Drugs? AWARD: $5,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 220 | POSTED: 9/14/12 Source: InnoCentive Challenge ID: 9932826 Type: Ideation Detailed Description & Requirements Background Productivity in drug discovery & development – the number of new drugs reaching patients – has been declining. At the same time, R&D spending has been increasing. Industry experts calculate the mean R&D spend per new drug on the market is $4-11 billion dollars. 2012 Forbes Article: The Truly Staggering Cost of Inventing New Drugs The Problem Various factors contribute to this high development cost. The most prominent is the high rate of attrition (failure) on drug like compounds as they pass through the drug development process. For every 10,000 compounds that appear interesting during basic research, 1 may reach market as an approved drug. Causes of compounds not progressing include: Lack of efficacy or potency Unfavorable pharmacology/pharmacodynamics Toxicity or safety Increasing regulatory stringency in approving drugs for clinical trial and for market Increasing emphasis on stratification of patient populations for administration of drugs (personalized medicine) Factors contributing to these causes include, but are not limited to: Assay systems and platforms that poorly replicate drug effects in humans Lack of new therapeutic drug targets being identified e.g. phenotypic screening data is difficult to convert into new molecular targets Animal experimental data, too, poorly predicts effects in humans / translational medicine Lack of good validated biomarkers to measure disease states or predict   [更多]

这项任务要要求设计一个自动化的，高通量的仪器 ， 可以定量地和可重复地测定的油水乳化液的分离。 这个任务需要提交一份书面建议书。 An Instrument for Quantitative, Reproducible Characterization of Water/Oil Emulsions AWARD: $30,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 508 | POSTED: 8/15/12 Source: InnoCentive Challenge ID: 9933086 Type: Theoretical-IP Transfer Detailed Description & Requirements The presence of emulsions in oil operations is common and generally undesirable. Crude oil emulsions typically form due to the presence of naturally occurring emulsifying agents (asphaltenes, resins, etc.) in crude oil. The high cost associated with transportation and corrosion of equipment is one of the problems caused by the presence of water in the crude oil. Therefore, oil dehydration is required, which is often achieved through chemical treatment using demulsifiers. While the Seeker has identified ~200 liquid “demulsifier” agents, compounds that in amounts of ~100-500 ppm can aid in the resolution of the water and oil phases, they lack a quantitative and reproducible assay for determining demulsifier effectiveness at resolving the emulsion. Currently, the Seeker performs a “bottle test” in which they add ~15-100 mL of the emulsion into a bottle, add the different demulsifiers, shake, and then visually observe which bottles show the best phase separation. This assay clearly relies on visual detection by a trained observer and is not nearly as quantitative or reproducible as the Seeker desires. Results from a bottle test with the same emulsion and three different demulsifiers are shown below. The bottle on the left has clearly not been resolved into two distinct phases. While the middle bottle shows significant improvement, careful inspection of the phase boundary shows a slight amount of oil contaminating the water layer and a slightly undefined interface. Finally, the bottle on the right shows an optimally resolved two-phase system with a very clear oil/water phase boundary. Important Note:   [更多]

任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。 Seeking Bicyclic Aminoketones AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12 Source: InnoCentive Challenge ID: 9932910 Type: RTP Detailed Description & Requirements Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references: Synthesis, 1, 1979, 50. Synthesis, 3, 2010, 493. Tetrahedron, 68 (4), 2012, 1286. J. Organic Chem, 73 (6), 2008, 2114. J. Med. Chem, 37 (18), 1994, 2831. More specifically, the Seeker is looking for compounds that meet the following Requirements: Structure: FeatureRange StructureA bicyclic aminoketone as shown in the structures above. Elements in R and A groupsR = H, Me, or protecting group (preferably Boc) A = A 1-3 membered linker where one atom may be N, O, or S Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F. Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups. Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle. Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider   [更多]

这是一项关于寻找材料加工技术的任务，要求是要用纳米团簇生产含能材料，这个技术的重点要是在一个可控的过程中进行，要有稳定的空气和粒子率增加一致。 这个任务需要提交一份书面的建议书 Energetic Core-Shell Nanocluster Production AWARD: $20,000 USD | DEADLINE: 11/19/12 | ACTIVE SOLVERS: 116 | POSTED: 9/19/12 Source: InnoCentive Challenge ID: 9932739 Type: Theoretical-licensing Detailed Description & Requirements Background Core-shell nanoclusters are groups of atoms of usually 2 materials in an arrangement such that one material, in the center, is the “core” of atoms which is coated with atoms of another material or the “shell”. These clusters contain from 10’s to millions of atoms and aggregates are in the nanometer range (~5 to 1000 nm). An example would be a core of Fe atoms and a shell of Au atoms. The Fe would not be stable as it would oxidize quite rapidly on its own, but the gold shell protects it from oxidation, yet the small clusters still exhibit magnetic behavior. This is the most simplistic core-shell and there are many different arrangements with multiple materials and multiple shells and the Solvers can look at the references attached for more information. Nanoclusters are unique as they exhibit properties different from bulk materials which are many times cluster size dependent. Of particular interest are highly energetic materials such as mixtures of metals and metal oxides. As nanoclusters, these materials have increased reactivity, because mass transport is removed as a barrier between fuel and oxidizer (i.e. all atoms are in intimate contact). Using the classic thermite reaction, an Al core of atoms could be coated with Fe Oxide which would protect the Al from oxidation. When ignited as nanoclusters the reaction rate would be increased over the bulk materials. The Challenge The Seeker is interested in material processing technologies for the production or fabrication of nano-scale core-shell cluster energetic materials with particle diameters between 5 and 25 nm. This process has been done in   [更多]

寻找一个有经验的会不锈钢金属蚀刻技术的合作伙伴。要求该合作伙伴精通蚀刻工艺的精度控制，并且具备大规模的生产能力，能在未来起到重要作用。 这是一项寻找合作伙伴的任务，要求提交一份关于建立合作伙伴关系的书面建议书。 Precise Chemical Metal Etching AWARD: varies | DEADLINE: 11/09/12 | ACTIVE SOLVERS: 6 | POSTED: 9/25/12 Source: InnoCentive Challenge ID: 9933182 Type: eRFP Detailed Description & Requirements Background The Seeker has a product whose parts are made by the precise chemical etching of thin Stainless Steel sheets. Stainless steel etching is not very common for precision parts because the requirements are usually too strict for the etching techniques due to underetching. The Seeker has pushed the limits of the metal etching process and has developed processes that potentially work for their application. The Seeker is now looking for partners who can do precision SS etching to potentially become suppliers of parts that will number in the hundreds of millions per year in total. The partner will have developed their own specialized etching technique to make the structures required. The Challenge and Opportunity We are seeking companies which are specialized in chemical metal etching of stainless sheet steel (~200 – 300 ?m thickness). The desired partner should be able to produce the structures on the template below using an etching technique. (Note: For easier viewing, a larger copy of the drawing is attached to this Challenge.) We do not expect the Solvers to actually produce the template structures for this Challenge, but show that they have the skills and equipment to potentially produce the structures. If selected as a potential partner by the Seeker after the Challenge, then you will be asked to produce the structures directly for the Seeker. The template is not the actual part of interest, but the Seeker is confident if you can reproduce the template, then it will translate to making the part. Figure 1- Etching Structure Template It should absolutely be clear that when using an etching technique, the   [更多]

Disulfiram 我想要一份USP版本的分析单   [更多]

有没在药企做持续改进、精益生产、IE的同行，提供下药厂精益生产项目、持续改进项目案例等，及精益生产实施计划、保障措施等等全套资料   [更多]

本人从事基层医疗10几年了 接触最多的就是电焊工 平时我都是用我自己配置的中成药药水帮电焊工洗眼 效果比日本的电焊眼药水不知道好多少倍 基本没有副作用 现在国家对日本眼药水的控制而使日本眼药水绝迹 市面上的电焊眼药水效果都不理想 所以才想到把我的配方推出来，但不知道怎么操作，特寻求帮助，条件你来开，我只想推出我的电焊工的专用眼药水。   [更多]

寻求乳化技术培训和指导 口服乳剂、外用乳剂和注射用乳剂涉及的先进乳化技术的培训和指导，重点解决乳剂容易出现的稳定性和防腐问题。 要求技术提供单位最好是重庆本地的机构。 技术需求单位：重庆健能医药开发有限公司   [更多]