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文献标题: 1.Micronization of Active Pharmaceutical Ingredients (API) – from R&D to the production scale 作者：S Mende 2. Crit Care Med. 2011 Feb;39(2):259-65. doi: 10.1097/CCM.0b013e3181feeb15. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Boyd JH1, Forbes J, Nakada TA, Walley KR, Russell JA. 3. Crit Care Med. 2006 Feb;34(2):344-53. Sepsis in European intensive care units: results of the SOAP study. Vincent JL1, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D; Sepsis Occurrence in Acutely Ill Patients Investigators. 4.Pharmacokinetic comparison and bioequivalence evaluation of?losartan/ hydrochlorothiazide tablet between Asian Indian and Japanese volunteers. Kumar S,?Monif T,?Khuroo A,?Reyar S,?Jain R,?Singla AK,?Kurachi K. 5.Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics 6.Dev Sci. 2014 Nov;17(6):977-83. doi: 10.1111/desc.12171. Epub 2014 Mar 17. Follow the liar: the effects of adult lies on children's honesty. Hays C1, Carver LJ. 7.Investigation of bioequivalence of a new fixed-dose combination of acarbose and metformin with the corresponding loose combination as well as the drug-drug interaction potential between both drugs in healthy adult male subjects. 要求: 打包上传符合要求的文献的PDF格式   [更多]

文献标题: 1.Development and evaluation of chitosan based oral controlled matrix tablets of?losartan?potassium J Pharm Investig.?2012 Jul;2(3):157-61. doi: 10.4103/2230-973X.104399. 2.Response criteria of tolvaptan for the treatment of hepatic edema J Gastroenterol. 2017 Jun 29. 3.Hepatol Res.?2017 Oct 6. doi: 10.1111/hepr.12988. [Epub ahead of print] Increased?serum?C-reactive?protein?and?decreased?urinary?aquaporin?2?levels?are?predictive?of the?efficacy?of?tolvaptan?in?patients?with?liver?cirrhosis. 4.Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range. 5.An evaluation of fit factors and dissolution efficiency for the comparison of in vitro dissolution profiles 6.Anatol J Cardiol.?2017 Sep;18(3):213-214. doi: 10.14744/AnatolJCardiol.2017.8033. Tolvaptan?in the very elderly with acute decompensated heart failure- a therapeutic option worth of consideration. 7.紫外-可见分光光度法测定依达拉奉注射液中的亚硫酸氢钠含量 8.Anatol J Cardiol. 2017 Sep;18(3):213-214. doi: 10.14744/AnatolJCardiol.2017.8033. Tolvaptan in the very elderly with acute decompensated heart failure- a therapeutic option worth of consideration. 备注: 将符合要求的文献PDF格式打包上传   [更多]

文献名称: 1.Sodium Diisopropylamide in Tetrahydrofuran: Selectivities, Rates, and Mechanisms of Arene Metalations 2.Advances toward LSD1 inhibitors for cancer therapy　 3.Serum HER2 extracellular domain levels and HER2 circulating tumor cell status in patients with metastatic breast cancer 4.Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder. 5.The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. 6. G.A. Digenis, The in vivo behavior of multiparticulate versus single unit dose formulations, CAPSUGEL’s Symposium in Seoul, 1990. 7.Stability of salicylic acid and magnesium stearate by DSC 作者：L Macpherson ， S Sauerbrunn 出版源：《American Laboratory》 , 2006 , 38 (14) :16-20 备注 : 将符合要求的文献PDF格式上传   [更多]

文献名称: 1.A Systematic Review and Meta-analysis of Efficacy and Safety of Novel Interleukin Inhibitors in the Management of Psoriatic Arthritis. J Clin Rheumatol. 2017 Sep 19. 2.A review article on brodalumab in the treatment of moderate-to-severe plaque psoriasis.Immunotherapy. 2017 Sep;9(12):963-978 备注 : 将符合要求的文献PDF格式上传   [更多]

文献名称: 1.Intensive induction chemotherapy with regimen containing intermediate dose cytarabine in the treatment of de novo acute myeloid leukemia. Am. J. Hematol. 2009, 84:422–427 2.15:05:49 憨出出 2017/10/11 15:05:49 EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis 3.Japan Guideline for treatment of chronic heart failure(JCS 2010) 备注: 将符合要求的文献PDF格式打包上传   [更多]

求DOF（Drugs of the future）2017年第6、7两期的文章（共17篇） 地址如下： https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_journal_home_pr?p_JournalID=2&p_VolumeID=42   [更多]

具体要求; 需要英国药典标准“Appendix XII B. Monographs of the British Pharmacopoeia”《 BP2017 》的药典标准一份.   [更多]

文献名称： 1、 A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids。British journal of Dermatology. Volume 157, Issue 5 November 2007 Pages 954-959 2、Tacrolimus ointment is more effective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis: Results from 3 randomized, comparative studies. JAAD. May 2005Volume 52, Issue 5, Pages 810-822 3、Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors. BJD Volume 165, Issue 3 September 2011 Pages 465-473 4、 Comparative Effectiveness of Topical Calcineurin Inhibitors in Adult Patients with Atopic Dermatitis . American Journal of Clinical Dermatology.April 2012, Volume 13, Issue 2, pp 113-123 5、Alikani M, Fauser BCJ, García-Valesco JA, Simpson JL, Johnson MH. Response from the Editors: first birth following spindle transfer. Reprod Biomed Online. 2017 Jul 20. pii: S1472-6483(17)30308-5. doi: 10.1016/j.rbmo.2017.07.002. [Epub ahead of print] PubMed PMID: 28781009. 6、Alikani M, Fauser BCJ, García-Valesco JA, Simpson JL, Johnson MH. First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation. Reprod Biomed Online. 2017 Apr;34(4):333-336. doi: 10.1016/j.rbmo.2017.02.004. PubMed PMID: 28385333. 7、 Simpson JL. Reproducing genetics. Genet Med. 2015 Jun;17(6):512-4. doi: 10.1038/gim.2015.37. PubMed PMID: 26035802. 8、Wou K, Feinberg JL, Wapner RJ, Simpson JL. Cell-free DNA versus intact fetal cells for prenatal genetic diagnostics: what does the future hold? Expert Rev Mol Diagn. 2015;15(8):989-98. doi: 10.1586/14737159.2015.1051529. Epub 2015 May 31. Review. PubMed PMID: 26027684. 9、Zhao S, Li G, Dalgleish R, Vujovic S, Jiao X, Li J, Simpson JL, Qin Y, Ivanisevic M, Ivovic M, Tancic M, Al-Azzawi F, Chen ZJ. Transcription factor SOHLH1 potentially associated with   [更多]

文献名称: 1、 Premedication with?Intravenous Ibuprofen?Improves Recovery Characteristics and Stress Response in Adults Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial. Le V, Kurnutala L, SchianodiCola J, Ahmed K, Yarmush J, Daniel Eloy J, Shapiro M, Haile M, Bekker A. Pain Med. 2016 Feb 18. pii: pnv113. [Epub ahead of print] 2、 A multicenter, randomized, double-blind placebo-controlled, single dose trial of the safety and efficacy of?intravenous ibuprofen?for treatment of pain in pediatric patients undergoing tonsillectomy. Moss JR, Watcha MF, Bendel LP, McCarthy DL, Witham SL, Glover CD. Paediatr Anaesth. 2014 May;24(5):483-9. doi: 10.1111/pan.12381. Epub 2014 Mar 20. 3、 Early?intravenous ibuprofen?decreases narcotic requirement and length of stay after traumatic rib fracture. Bayouth L, Safcsak K, Cheatham ML, Smith CP, Birrer KL, Promes JT. Am Surg. 2013 Nov;79(11):1207-12. 4、 Impact of oral versus?intravenous ibuprofen?on neurodevelopmental outcome: a randomized controlled parallel study. 5、 Ahn BO, Dong HK, Cho H, Kang KK, Park BS, Na KH, et al. Four-week Repeated Dose Toxicity Study of Recombinant Human Basic Fibroblast Growth Factor by Subcutaneous Administration in Rats. Toxicological Research. 1999;15. 6、 Dong HK, Cho H, Kang KK, Ahn BO, Kim WB. Acute Toxicity Study on Recombinant Human Basic Fibroblast Growth Factor in Rats and Dogs. Toxicological Research. 1999;15. 7、 Meduri A, Aragona P, Grenga PL, Roszkowska AM. Effect of basic fibroblast growth factor on corneal epithelial healing after photorefractive keratectomy. Journal of refractive surgery (Thorofare, NJ : 1995). 2012;28(3):220-3. Eras Z, Gokmen T, Erdeve O, Ozyurt BM, Saridas B, Dilmen U. Am J Perinatol. 2013 Nov;30(10):857-62. doi: 10.1055/s-0033-1333667. Epub 2013 Jan 28. 8、 Intravenous ibuprofen?for postoperative pain. Kroll PB. Pain Manag. 2012 Jan;2(1):47-54. doi: 10.2217/pmt.11.68. 9、 A multicenter, randomized, double-blind,   [更多]

需求文献： 1、DAWSON PA， KARPEN SJ． Bile acids reach out to the spinal cord： new insights to the pathogenesis of itch and analgesia in cholestatic liver disease ［J］． Hepatology， 2014， 59 （4）：1638－1641． 2、Kremer AE, van Dijk R, Leckie P, et al. Serum autotaxin is increased in pruirtus of cholestasis, but not of other oirgin, and responds to therapeutic interventions[J]. Hepatology, 2012(56): 1391-1400. 3、Long-term clinical impact and cost-effectiveness of obeticholic acid for the treatment of primary biliary cholangitis. Sumeyye Samur,Matthew Klebanoff,Reiner Banken,Daniel S. Pratt. 《Hepatology》 , 2017 , 65 (3) :920. 4、Obeticholic acid for PBC. Hugh Thomas. Nature Reviews Gastroenterology & Hepatology 13, 558-559 (2016). 5、Emerging and future therapies for nonalcoholic steatohepatitis in adults. Gesthimani Mintziori , Stergios A. Polyzos. 《Expert Opinion on Pharmacotherapy》 , 2016 , 17 (14) :1 -10. 6、9、Obeticholic acid for the treatment of primary biliary cirrhosis. Trivedi PJ, Hirschfield GM, Gershwin ME. Expert Rev Clin Pharmacol. 2016;9(1):13-26. doi:10.1586/17512433.2015.1092381. Epub 2015 Nov 7. 7、Kowdley K，Nevens F，Andreone P，et al． The first new trials for primary biliary cirrhosis in a decade: an international program evaluating the farnesoid X receptor agonist obeticholic acid［J］． Gastroenterology，2015，1481 ( 4) : S991-S992． 8、Treatment of Non-Alcoholic Fatty Liver Disease . Scherer A., Dufour J.-F. 9、Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers. Pencek R, Marmon T, Roth JD, Liberman A, Hooshmand-Rad R, Young MA. Diabetes Obes Metab. 2016 Sep;18 (9):936-40. doi: 10.1111/dom.12681. Epub 2016 Jun 6. 10、Metabolite profiling of CHO cells with different growth characteristic 11、Sun, Zhaoyun; Peng, Xinhua; Dong, Xiongzi; Shi, Wenwen - Asian Journal of Chemistry, 2012, vol. 24, # 2, p. 929 - 930 要求：下载符合需求的文献PDF格式打包上传   [更多]