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我们需要设计自动崩解控制器用于靶向给药。自动崩解控制器，一旦触发，应该可以在温和条件(生理)下使药物分子的释放并激活。这个我们可以参考数量有限的文献中描述“self-immolative”（自动分解或自毁）连接器，但我们提出的自动崩解控制器不是这样的装置。具体链接为https://www.innocentive.com/ar/challenge/9933733，具体如下： Design of A Self-Cleaving Linker For Targeted Drug Delivery TAGS: Physical Sciences, Novel Molecules, Chemistry, Life Sciences, Theoretical-IP Transfer AWARD: $25,000 USD | DEADLINE: 4/27/15 | ACTIVE SOLVERS: 165 | POSTED: 3/26/15 The Seeker desires the design of a novel self-cleaving linker for use in targeted drug delivery. The self-cleaving linker, once triggered, should allow for the release of molecule(s) of interest under mild (physiological) conditions. A limited number of “self-immolative” linkers are well described in the literature and are specifically excluded from this Challenge. The Seeker specifically encourages synthetic chemists to consider this Challenge even if they do not have medicinal chemistry knowledge. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933733 Challenge Overview The Seeker desires the design of a novel self-cleaving linker for use in targeted drug delivery. The self-cleaving linker, once triggered, should allow for the release of molecule(s) of interest under mild (physiological) conditions. A limited number of such “self-immolative” linkers, based upon an elimination to generate a quinone methide, or utilizing a 5 or 6 member ring cyclization, are well described in the literature and are specifically excluded from this Challenge. The Seeker specifically encourages synthetic chemists to consider this Challenge even if they do not have medicinal chemistry knowledge. This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker. To receive an award, the Solvers will have to transfer to the Seeker their exclusive Intellectual Property   [更多]

这项任务要要求设计一个自动化的，高通量的仪器 ， 可以定量地和可重复地测定的油水乳化液的分离。 这个任务需要提交一份书面建议书。 An Instrument for Quantitative, Reproducible Characterization of Water/Oil Emulsions AWARD: $30,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 508 | POSTED: 8/15/12 Source: InnoCentive Challenge ID: 9933086 Type: Theoretical-IP Transfer Detailed Description & Requirements The presence of emulsions in oil operations is common and generally undesirable. Crude oil emulsions typically form due to the presence of naturally occurring emulsifying agents (asphaltenes, resins, etc.) in crude oil. The high cost associated with transportation and corrosion of equipment is one of the problems caused by the presence of water in the crude oil. Therefore, oil dehydration is required, which is often achieved through chemical treatment using demulsifiers. While the Seeker has identified ~200 liquid “demulsifier” agents, compounds that in amounts of ~100-500 ppm can aid in the resolution of the water and oil phases, they lack a quantitative and reproducible assay for determining demulsifier effectiveness at resolving the emulsion. Currently, the Seeker performs a “bottle test” in which they add ~15-100 mL of the emulsion into a bottle, add the different demulsifiers, shake, and then visually observe which bottles show the best phase separation. This assay clearly relies on visual detection by a trained observer and is not nearly as quantitative or reproducible as the Seeker desires. Results from a bottle test with the same emulsion and three different demulsifiers are shown below. The bottle on the left has clearly not been resolved into two distinct phases. While the middle bottle shows significant improvement, careful inspection of the phase boundary shows a slight amount of oil contaminating the water layer and a slightly undefined interface. Finally, the bottle on the right shows an optimally resolved two-phase system with a very clear oil/water phase boundary. Important Note:   [更多]

　　需求以上三种大生产成熟工艺，有设备，成本优势，非诚勿扰，谢谢。   [更多]

主要内容和技术经济指标 1、利用食用菌废培养料制成块煤，对引进的技术及设备进行改进。将食用菌废培养料里的秸秆、锯末等材料通过粉碎、煤化处理，使用秸秆压块机械压制成块煤。 2、利用食用菌废培养料制成有机肥，通过对不同发酵菌种的试验，确定最优的发酵菌种及方法。采用生物有机肥发酵专用菌种 处理废弃培养料，可大量分解作物所必须的葡萄糖、氨基酸、维生素群、生长素等活性物质和氮、磷、钾、微量元素。 3、利用食用菌废培养料生产畜禽饲料，通过对不同发酵菌剂及方法的试验，确定最佳组合方案。应用生物菌剂和粗饲料降解剂对菌渣进行降解处理后，将其作为禽畜的饲料添加剂。 技术指标：食用菌废培养料制成块煤:块煤热值＞18000kJ/kg，密度为1.2-1.5 g/cm3，生产率为1500kg/h。食用菌培养料棒制成有机肥：发酵时间为7－9天，翻抛机生产率＞250m3/h。食用菌废培养料生产畜禽饲料：发酵时间为3－8天。   [更多]

具体要求：1、按照《药物警戒质量管理规范》要求撰写； 2、适用于生产企业； 3、拿来直接能用。 交稿方式：直接点击交稿在线交稿，我会每天过来看的，谢谢各位药智的战友们。   [更多]

寻求改善和提高创可帖和医用胶带涂胶层的持粘性和剥离强度，主要内容和技术经济指标 目前我公司生产的创可帖和医用胶带多采用涂胶工艺，为了满足国内，尤其是国外客户的需要，需要进一步提高涂胶层的持粘性和剥离强度。我们需要相关配方和工艺，尤其欢迎在现有配方的基础上加以改进和调整的方案。   [更多]

　现需求 咯菌腈成熟大生产技术!有的请投标。   [更多]

要求：生产过程中提供技术指导，提高氟宁精氨酸酯药物利用率，降低生产成本，提高工作效率   [更多]

需要具体的检测方法，检测所需器材。   [更多]

RT，要求上述所罗列项目包括了菌种、发酵工艺、后提取精制工艺及相应的参数指标。   [更多]