这是高速度的药物API的片剂压制的一个主要问题。活性药物成分在压冲过程中的冲头被粘住而使片剂重量和剂量有所损失产生不同。我们寻找一种计算片剂压片机高速冲头上剂量和重量损失的模型，用以改进片剂工艺。具体请看下面英文描述：https://www.innocentive.com/ar/challenge/9933670
AWARD: $10,000 USD | DEADLINE: 2/22/15 | ACTIVE SOLVERS: 9 | POSTED: 1/23/15
Solid dosage forms (e.g. tablets) are the preferred dosage unit for pharmaceutical products. These units are produced by compressing particulate formulations. A major problem in the high speed pressing of tablet formulations of pharmaceutical API’s (Active Pharmaceutical Ingredient) is they sometimes tend to stick to the punches during the compression process. This causes weight loss defects in the tablets and thus costly manufacturing defects during production. A model is required to predict sticking of formulations in high speed presses to prevent losses in production.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution.
Source: InnoCentive Challenge ID: 9933670
Challenge Overview
Tablets are the main dosage form of choice for medicines. They have manufactured by compressing formulations which may consist of blended powders or granules. A major problem in the high speed pressing of tablet formulations of new medicines is they sometimes tend to stick to the surfaces of compaction equipment. This causes tablet weight and hence dose reduction and thus costly manufacturing defects during production. The phenomenon is frequently only observed on scale up due to the lengthy run times at large scale and is difficult to reproduce at smaller scales. New models (or partial model concepts) are required to improve the overall modeling of “stickiness” in tablet compression and predict the extent beforehand. Suggestions for improvements to either process route or equipment or to formulation ingredients to prevent sticking from the models are also desired.
This is an Ideation Challenge, which has the following unique features:
There is a guaranteed award. The awards will be
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