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摘要： 这项任务是寻找一种新的配方，合成除虫菊酯缓释制剂。 要求改变其生物活性化合物的挥发，使其的生物活性超过一年。这项配方必须要有足够的稳定性，即使是在热带环境中放几年也不受影响。并且所得的制剂在跟水稀释后能喷洒或涂刷在表面。要求这个配方必须使用常用的材料和国家最先进的制造工艺，并且对人体和环境是安全的。 这项任务需要提交一份详细的书面报告。 具体要求： Sustained Release Formulation for Synthetic Pyrethroids TAGS: Food/Agriculture, Chemistry, Physical Sciences, Theoretical-IP Transfer AWARD: $25,000 USD | DEADLINE: 12/16/12 | ACTIVE SOLVERS: 10 | POSTED: 10/16/12 The Seeker is looking for a novel formulation that modifies the volatility of a biologically active compound to give a product with activity of more than one year. The formulation should be stable for several years of storage even under tropical conditions. The resulting formulation should be able to be applied by spraying or by brushing etc. after dilution with water on many surfaces. The Seeker requires that the formulation technique must use commonly available materials and state of the art manufacturing process, as well as be safe for humans and the environment. This Challenge requires only a written proposal. Sustained Release Formulation for Synthetic Pyrethroids Detailed Description & Requirements INTRODUCTION The Seeker is keenly interested in finding a “new and novel” approach to formulation that will stabilize a volatile synthetic bioactive, for a full year after application via sprayed or brushed-on use scenarios, yet protected from its typical routes of decomposition. The formulation must be considered safe for humans and the environment, and it must be cost-effective to manufacture from commodity-type materials using state-of-the-art manufacturing processes. DETAILS OF COMPOUND TO BE FORMULATED The active the seeker is interested in belongs to the chemical class of synthetic pyrethroids (http://en.wikipedia.org/wiki/Pyrethrin). It has a molecular weight of approx. 400, a vapor pressure of about 1mPa at 25°C, a very poor solubility in water but high in non-polar media. Types of   [更多]

最近在美国，天然气的可用性范围大大提高。这将潜在的影响天然气转化成化学物质的进程，比如目前来自原油的烯烃和芳烃。这个任务就是需要找到使天然气转换成主要的化学和化工原料的新方法。 这是一个思维方法的挑战，保证至少会奖励一名合格者。 应征稿件请直接上传网址：https://www.innocentive.com Natural Gas Conversion to Chemicals TAGS: Engineering/Design, Chemistry, Physical Sciences, Ideation AWARD: $15,000 USD | DEADLINE: 10/28/12 | ACTIVE SOLVERS: 126 | POSTED: 9/28/12 Recent developments show a large increase in Natural Gas (NG) availability in the US. This leads to the potential for processes to convert NG to chemicals that are currently derived from crude oil such as olefins and aromatics. The Seeker is looking for novel ideas for methods to convert Natural Gas to a major chemical or chemical feedstock beyond those processes known today. This is an Ideation Challenge with a guaranteed award for at least one submitted solution. Detailed Description & Requirements Background Recent developments show a large increase in Natural Gas (NG) availability in the US; novel production methods to extract NG from shale reservoirs have reversed forecasts from the US becoming a net gas importing to a net gas exporting country. On the demand side, gas utilization is favored because it has the lowest CO2 emissions /energy ratio. At the same time, crude oil availability (as simply observed from its price) has been limited. In general, the gas-oil differential has been widening in the recent past and there are reasons to believe this broad gap will be continued well into the future. This outlook offers interesting potential for processes to convert NG to products that are currently derived from crude oil, e.g. (liquid) transportation fuels and chemical feedstock as olefins and aromatics. Some processes already exist, for example: Gas-To-Liquids, GTL, process converting NG via synthesis gas intermediate (a mixture with varying ratios of hydrogen and carbon monoxide, often containing carbon dioxide as well) to paraffinic products using Fischer-Tropsch   [更多]

求购磷酸肌酸钠精制工艺, 标准为1g溶于10g水中，无杂质，具体要求见附件   [更多]

现我公司需要生产一些软袋样品，希望能找一个公司的软袋输液生产线代为加工生产，加工费价格好商量，如果能介绍成功，给予1000元介绍费。 联系QQ：1620567963   [更多]

　　求购孟鲁司特钠大生产合成工艺，如工艺真实，重复性好，现金支付酬金。   [更多]

“洗衣粉漂洗泡沫控制技术” 对象 我们希望合作伙伴能够提供外源专业技术，以找到一种能够有效及高效地抑制洗衣粉漂洗泡沫而同时又不会影响洗涤泡沫及(或)清洗效果的新技术。 背景 在洗衣过程中，消费者非常重视洗衣粉的泡沫量，特别是手洗时。 我们希望有一种技术能够有选择性地抑制漂洗阶段的泡沫量，而同时不影响洗涤阶段的泡沫量。 要实现此目标所面临的挑战涉及两个看起来相互矛盾的流程：添加剂必须能够在漂洗阶段有效地抑制泡沫量。 然而，该添加剂在洗涤阶段必须保持非活性状态，不得影响洗涤中的泡沫量。 目标 我们需要的是： A. 能够有选择性地在首次漂洗过程中抑制 90% 的泡沫量。 B. 对洗涤中的泡沫量影响较少或无影响，洗涤泡沫量与添加前相比，至少保持原泡沫量的 80%. 成功标准 评判解决方案是否成功的关键准则包括： · 在首次漂洗过程中能够抑制 90% 以上的泡沫量。 · 洗涤过程中对泡沫的抑制量不超过 20%。 · 不会对清洗效果和织物净白产生不良影响 · 满足人身和环保安全法规 · 不会显著地影响产品的稳定性，时间长时不会出现变色或变味。 · 具有让产品占据专有地位及推进产品优势声明的可能。 · 价格可行。 其性能将在洗衣粉中进行评估。 其他重要信息 Ø 需要提供相应的样品，以由宝洁公司进行初始检测。初始样品的数量应为 0.2-5 千克。 有关回应的其他评估标准 宝洁公司将采用如下标准对各响应进行评估： · 所提议方法的整体科学和技术优点 · 用于保证实现其设计概念或性能的方法 · 实现专有地位的可能(即技术的创新性或可申请专利性) · 所提议概念的经济潜力 · 提供方的实力及相关经验 · 规模生产和商业化所需的时间 保密 提交回应，表明您认同了所提交的回应中不包含任何类型的保密性信息。 如果需要，可提供一份 CDA 以便能够更加详细的讨论或是交流信息。 稿件提交网址：宝洁联系与发展网http://www.pgconnectdevelop.cn   [更多]

需求描述： 口腔硬组织很容易聚集牙垢和牙菌斑。需要确定经证明能防沉积并轻松去除沉积物的技术和产品。 我们寻求： 比传统口腔护理产品(牙膏和漱口水)防附着性能更强的产品 ¨ 益处能持续一段时间(距离下一次刷牙)且比目前市场上的口腔护理产品更优越 ¨ 技术/产品必须与钠和氟化亚锡相容 ¨ 防附着机制必须不影响牙釉质吸收氟 所关注的益处 预防牙菌斑 预防牙垢 预防牙结石 ¨ 产品形式可包括 牙膏(液态) 漱口水(液态) 凝胶(非液态) ¨ 最好是具有下列特征的技术： 从软硬组织沉积、留存并释放物质的技术 所有基于液态的口腔护理制剂均有性能、稳定性和相容性相关数据 有相当于适当阴性对照组的性能数据(技术/消费者/临床) 有能证明和量化益处的独特能力 人体安全性已得到确认或材料得到美国公认安全认证(GRAS) 使用产品后有明显清洁感 获得专利保护 我们对下列技术不感兴趣： 不受强有力知识产权保护的技术 需要广泛的安全许可或监管部门批准的技术 稿件提交网址：宝洁联系与发展部http://www.pgconnectdevelop.cn   [更多]

RT，要求上述所罗列项目包括了菌种、发酵工艺、后提取精制工艺及相应的参数指标。   [更多]

这项任务要要求设计一个自动化的，高通量的仪器 ， 可以定量地和可重复地测定的油水乳化液的分离。 这个任务需要提交一份书面建议书。 An Instrument for Quantitative, Reproducible Characterization of Water/Oil Emulsions AWARD: $30,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 508 | POSTED: 8/15/12 Source: InnoCentive Challenge ID: 9933086 Type: Theoretical-IP Transfer Detailed Description & Requirements The presence of emulsions in oil operations is common and generally undesirable. Crude oil emulsions typically form due to the presence of naturally occurring emulsifying agents (asphaltenes, resins, etc.) in crude oil. The high cost associated with transportation and corrosion of equipment is one of the problems caused by the presence of water in the crude oil. Therefore, oil dehydration is required, which is often achieved through chemical treatment using demulsifiers. While the Seeker has identified ~200 liquid “demulsifier” agents, compounds that in amounts of ~100-500 ppm can aid in the resolution of the water and oil phases, they lack a quantitative and reproducible assay for determining demulsifier effectiveness at resolving the emulsion. Currently, the Seeker performs a “bottle test” in which they add ~15-100 mL of the emulsion into a bottle, add the different demulsifiers, shake, and then visually observe which bottles show the best phase separation. This assay clearly relies on visual detection by a trained observer and is not nearly as quantitative or reproducible as the Seeker desires. Results from a bottle test with the same emulsion and three different demulsifiers are shown below. The bottle on the left has clearly not been resolved into two distinct phases. While the middle bottle shows significant improvement, careful inspection of the phase boundary shows a slight amount of oil contaminating the water layer and a slightly undefined interface. Finally, the bottle on the right shows an optimally resolved two-phase system with a very clear oil/water phase boundary. Important Note:   [更多]

任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。 Seeking Bicyclic Aminoketones AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12 Source: InnoCentive Challenge ID: 9932910 Type: RTP Detailed Description & Requirements Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references: Synthesis, 1, 1979, 50. Synthesis, 3, 2010, 493. Tetrahedron, 68 (4), 2012, 1286. J. Organic Chem, 73 (6), 2008, 2114. J. Med. Chem, 37 (18), 1994, 2831. More specifically, the Seeker is looking for compounds that meet the following Requirements: Structure: FeatureRange StructureA bicyclic aminoketone as shown in the structures above. Elements in R and A groupsR = H, Me, or protecting group (preferably Boc) A = A 1-3 membered linker where one atom may be N, O, or S Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F. Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups. Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle. Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider   [更多]