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控制体内血糖水平是成功治疗许多疾病的关键，如糖尿病。 因此， Novo Nordisk公司正在寻找新的小分子，它可以于D-葡萄糖的生理集合密切结合 (持续的取代，Kd，低毫摩尔范围) 悬赏须提交概念性实验数据报告和样品，Novo Nordisk公司将决定最终得奖者，并颁发起始奖金200000美金。 另外Novo Nordisk公司将提议基于里程碑式的合约，如果分子式在未来悬赏中得到成功研发，将会得到二次奖项。 悬赏截止时期2017年1月9日, 投标网址：https://www.innocentive.com/ar/projectRoom/index?challenge=9933823 原文: Novo Nordisk Challenge: Design and Synthesis of a Small Molecule Glucose Binder TAGS: Chemistry, Life Sciences, Royal Society of Chemistry, RTP AWARD: $200,000 USD | DEADLINE: 1/09/17 | ACTIVE SOLVERS: 145 | POSTED: 3/30/16 The control of glucose levels in the body is key for successful treatment of many disease states such as diabetes. Hence, Novo Nordisk is looking for novel small molecules that can bind with affinities matching the physiological concentrations of D-glucose (displacement constant, Kd, in the low millimolar range). This is a Reduction-to-Practice Challenge that requires written documentation, experimental proof-of-concept data, and sample delivery. Additionally, the Challenge has the following unique features.Please read carefully the Challenge-Specific Agreement. • Solvers are asked to prepare the compound and perform binding affinity assays to glucose in aqueous solution under conditions described in the Challenge Description. The compounds must also be supplied to Novo Nordisk in sufficient amounts to reproduce the results. Upon experimental validation of the results, Novo Nordisk will make an award (‘Initial Transfer Fee’) of $200,000 to the best solution as solely determined by the Seeker, according to the Challenge requirements. The Awarded Solver grants Novo Nordisk an exclusive license under the terms described in the Challenge-Specific Agreement. • Additionally, Novo Nordisk will offer a milestone-based agreement to the Solver, establishing the terms of payment of anadditional award (‘Secondary Award’), should the small molecule be successful in its development post-Challenge(‘Second Evaluation Period’), in exchange   [更多]

Boehringer Ingelheim公司寻找一种有机小分子，能够安全使用，没有生物活性，或非常温和的生物活性，能够显示细胞的渗透性，并且在长期口服的情况下能够达到高血药浓度。 有机小分子常见于：药物化学，内科医师，配方科学（盖仑制剂），药剂学，药理学等领域。 有机小分子不常见于 ：动物医疗，农业科学，食物化学，营养学，化妆品，或其他等领域。 投标截止时期2016年6月26日, 投标网址：https://www.innocentive.com/ar/projectRoom/index?challenge=9933854 Seeking Safe Drug-like Small Organic Molecules for Human Use with Negligible Biological Effects TAGS: Chemistry, Life Sciences, Food/Agriculture, Royal Society of Chemistry, Ideation AWARD: $20,000 USD | DEADLINE: 6/26/16 | ACTIVE SOLVERS: 106 | POSTED: 4/27/16 Boehringer Ingelheim (The Seeker) is interested in small organic molecules that are safe for human use, show no, or very mild, biological activity, display cell permeability, and achieve high concentrations (µM) in the plasma when chronically administered via the oral route. This is an Ideation Challenge with a guaranteed award for at least one submitted solution. Source: InnoCentive Challenge ID: 9933854 Sign Agreement For This Challenge By electronically signing the agreement below, you are indicating your intention to view the details of this specific InnoCentive Challenge. Viewing the Challenge Details does not obligate you to perform any work on this challenge. Print this Agreement for your records InnoCentive Ideation Challenge-Specific Agreement Please Read This Carefully! You and InnoCentive are agreeing to a Challenge-Specific Solver Agreement for this particular InnoCentive Ideation Challenge only. The Seeker for this InnoCentive Challenge has required that you accept these special terms, so please take the time to understand them. If you click \\"I agree\\" and proceed to the Project Room for this InnoCentive Challenge, this Challenge-Specific Agreement (\\"CSA\\") will be a valid and binding agreement between you and InnoCentive and in addition to the existing Terms of Use for all purposes relating to this InnoCentive Challenge. Please print and keep a copy of this CSA. No provisions you may have   [更多]

碳酸氢钠是预防初期牙龈炎的一种活性成分，它存在各种牙膏中。当碳酸氢钠高浓度存在于牙膏中，非常咸的味道会令人不愉快。 悬赏任务是，在高浓度碳酸氢钠牙膏中，寻找一种掩盖咸味道的技术。 悬赏截止时期2016年7月31日, 投标网址：https://www.innocentive.com/ar/projectRoom/index?challenge=9933826 Masking Salty Taste TAGS: Royal Society of Chemistry, Chemistry, Food/Agriculture, Life Sciences, RTP AWARD: See details | DEADLINE: 7/31/16 | ACTIVE SOLVERS: 94 | POSTED: 5/05/16 Sodium bicarbonate is a salt that is used as an ingredient in various products for many applications across various industries. It has a particularly strong salty taste, hence in applications where it is ingested, the salty flavour is pronounced. That is the case in toothpastes, where the beneficial gum protection effect that sodium bicarbonate delivers is overshadowed by the unpleasant salty taste that is felt by consumers, making such toothpastes unpopular. Do you have a technology that can mask the salty taste and make it imperceptible in toothpastes? This is a Reduction-to-Practice Challenge that requires written documentation, experimental proof-of-concept data, and, if requested by the Seeker, sample delivery. Source: InnoCentive Challenge ID: 9933826 Sign Agreement For This Challenge By electronically signing the agreement below, you are indicating your intention to view the details of this specific InnoCentive Challenge. Viewing the Challenge Details does not obligate you to perform any work on this challenge. Print this Agreement for your records InnoCentive RTP Challenge-Specific Agreement Please Read This Carefully! You and InnoCentive are agreeing to a Challenge-Specific Solver Agreement for this particular InnoCentive Challenge only, as permitted in the Terms of Use. The Seeker for this InnoCentive Challenge has required that you accept these special terms, so please take the time to understand them. If you click \\"I agree\\" and proceed to the Project Room for this InnoCentive Challenge, this Challenge-Specific Agreement (\\"CSA\\") will be a valid and   [更多]

通常粘合假牙的化学物会从边缘过量留出，造成的在口中含有化学味道，同时伴随红肿等不良性。寻求一种取代现有的粘合技术，从而改善顾客体验的一种新的技术。 投标截止时期2016年6月5日, 投标网址：https://www.innocentive.com/ar/challenge/9933824 Seeking New Technologies for Denture Adhesives TAGS: Chemistry, Physical Sciences, Life Sciences, Engineering/Design, Theoretical-IP Transfer AWARD: $20,000 USD | DEADLINE: 6/05/16 | ACTIVE SOLVERS: 50 | POSTED: 5/05/16 The use of denture adhesives often comes with an unpleasant sensorial experience for the user, for example, an unpleasant chemical taste, “swelling” and over-flow of the product (oozing) from the edges of the denture and a grainy texture in the mouth. The Seeker for this Challenge is looking to improve this experience for consumers, hence is seeking novel alternative adhesive technologies that can better the sensorial experience without compromising holding performance. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933824 Sign Agreement For This Challenge By electronically signing the agreement below, you are indicating your intention to view the details of this specific InnoCentive Challenge. Viewing the Challenge Details does not obligate you to perform any work on this challenge. Print this Agreement for your records InnoCentive Theoretical (IP Rights Transfer) Challenge-Specific Agreement Please Read This Carefully! You and InnoCentive are agreeing to a Challenge-Specific Solver Agreement for this particular InnoCentive Challenge only, as permitted in the Terms of Use. The Seeker for this InnoCentive Challenge has required that you accept these special terms, so please take the time to understand them. If you click \\"I agree\\" and proceed to the Project Room for this InnoCentive Challenge, this Challenge-Specific Agreement (\\"CSA\\") will be a valid and binding agreement for all purposes relating to this InnoCentive Challenge and in addition to your agreement to abide by the Terms of Use when you registered as a Solver.   [更多]

理论分析一种材料，能有明显区分其与丙酮或水（潮湿）的物理作用。如膨胀，收缩，卷曲，等等。此材料不限于纤维，膜剂或织物。 “请于2016年5月23日之前将稿件上传到：https://www.innocentive.com/ar/challenge/9933858 “ Challenge Overview Many materials (usually polymers) change shape when exposed to acetone (ketones in general) but also have a large affinity for moisture as well. It would be very difficult to attribute physical changes to acetone or water if both were present. The Seeker is looking for materials and associated processes that produce an observable physical change to the substrate upon exposure to acetone. The material should not have the same effect when exposed to moisture so the two can be differentiated. The effect should be reversible and the rate of absorb/desorb should be similar. This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker. To receive an award, the Solvers will have to transfer to the Seeker their exclusive Intellectual Property (IP) rightsto the solution. However, the Seeker will be willing to consider a licensing agreement for a partial award if exclusive IP cannot be transferred by the Solver. Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on May 23, 2016. Late submissions will not be considered.   [更多]

求购“Abiraterone Acetate Tablets”《 USP39-NF34 》的药典标准一份.   [更多]

最好是PDF 版的   [更多]

求购列吡嗪片日本药典2015版标准，英国药典2015版标准，美国药典38版标准   [更多]

1、有关改善机体亚健康疲劳综合证的 2、要求纯中药制剂且原料易得。 3、化药复方制剂也行。 4、预防和治疗老年知呆症的   [更多]

需要该标准的全文信息！！！   [更多]