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苦木的化学成分研究资料------在苦木中分离的化合物，要有具体的分离方法，每个化合物有原始打印的H谱和C谱，有紫外红外更好。有这些资料的联系我，高价格商谈！   [更多]

（1）4-甲氧基-5羟基-铁屎米酮 cas：18110-86-6 （2）4，5-二甲氧基铁屎米酮 cas:18110-87-7 (3) 3-甲基-铁屎米酮-2,6-二酮 有做过苦木生物碱分离的研究生，手里有标准品的我们可以购买，如果能给我们分离也可以，需求量每种40-60mg。价格我们商谈！价钱好说   [更多]

勃林格殷格翰公司对诊断和治疗慢性阻塞性肺疾病以及重症哮喘患者新方法非常感兴趣。针对慢性阻塞性肺病患者或重症哮喘所造成的呼吸道障碍，他们积极寻求恢复方法并寻找分子靶点开发治疗药物。具体如下：（https://www.innocentive.com/ar/challenge/9933560） Boehringer Ingelheim (the Seeker) is interested in identifying new therapeutic concepts for the treatment of patients with chronic obstructive pulmonary disease (COPD) or severe asthma. The Seeker is specifically searching for molecular targets to develop therapeutic agents for the restoration of the airway epithelial barrier function in patients with COPD or severe asthma. The Seeker is also interested in molecular targets driving the regeneration of the airway epithelium. Submitted solutions that meet the Solution Requirements according to this InnoCentive Challenge Statement will be considered for up to three awards of $15,000 each. However, the Seeker may (i) not award any solution if none of the submitted proposals meets all Solution Requirements or (ii) award only the solution of the highest overall quality with $15,000. The consideration for an award requires the willingness and ability of the Solver to provide the Seeker with a non-exclusive license regarding all intellectual property related to the Challenge according to the terms of the InnoCentive Theroretical (Non-Exclusive-License) Challenge-Specific Agreement. 2. Additional application for Research Funding In addition to consideration for the award(s) Solvers with appropriate qualifications and expertise having access to a suitable research laboratory and equipment can apply for research funding (“Research Funding”) to execute a research plan that is proposed in the submitted solution. The requested funding should not exceed a funding period of 2 years and a total budget of $200,000. The selection of candidates for Research Funding will be conducted after completion of the Challenge, and will require the submission of additional information. The decision to fund research will be at the sole discretion of the Seeker. The Challenge according to No.   [更多]

我们对治疗克罗恩病和溃疡性结肠炎的新的机理和作用点感兴趣，这些可能包括，但不限于，接近病灶或调节菌群，代谢，遗传，后天产生的抗体。新治疗方法可能包括，但不限于，疫苗，基因治疗，和小分子化合物，而免疫抑制除外。理想的途径是先找到IBD发病新机理，再转化为一种治疗新的方法。具体如下：（https://www.innocentive.com/ar/challenge/9933446） Novel Treatment Approaches to Cure Inflammatory Bowel Diseases TAGS: Nature, Chemistry, Life Sciences, Ideation AWARD: $10,000 USD | DEADLINE: 2/16/15 | ACTIVE SOLVERS: 21 | POSTED: 12/16/14 The Seeker for this Challenge desires proposals describing potential approaches for curing Crohn’s disease and ulcerative colitis. The Seeker is interested in novel mechanisms of action that specifically address the pathogenesis of inflammatory bowel diseases (IBD). These may include, but are not limited to, approaches targeting or modulating the microbiota, metabolism, genetic, and epigenetic targets. Platforms may involve, but are not limited to, vaccines, gene therapy, and small molecule compounds. The Seeker is not interested in immunosuppression. Desirable approaches are specifically relevant to the pathogenesis of IBD and can be translated into a cure. This is an Ideation Challenge with a guaranteed award for at least one submitted solution. In addition to the Challenge award, the Seeker is open to establishing potential collaborations with the winning Solver(s) to further investigate proposed mechanisms with the eventual goal of developing a cure for IBD. Source: InnoCentive Challenge ID: 9933446 Challenge Overview The Seeker for this Challenge desires proposals for novel approaches that specifically address the causes of inflammatory bowel diseases (IBD) to enable the development of a cure. The Seeker is interested in unique ideas and new approaches (including gene delivery techniques), but is not interested in approaches that are simply common targets for various immunological conditions. That is, the approach must be specifically relevant to the pathogenesis of IBD and can be translated into a cure. This is an Ideation Challenge, which has   [更多]

Sibutramine的生产工艺   [更多]

重性抑郁障碍（MDD）是一种使人衰弱的精神障碍，在美国约有20000000流行病例。然而不同的抗抑郁药可用于治疗不同的抑郁症，，约50%的抑郁症患者的初始治疗结果不理想。最近有证据表明，在发病的几个小时内氯胺酮给药治疗难治性抑郁症已经显著有所改善。勃林格殷格翰公司寻找氯胺酮在人体中反应和持续的抗抑郁作用的机理。 Boehringer Ingelheim Challenge: Understanding the Antidepressant Effect of Ketamine TAGS: Nature, Chemistry, Life Sciences, Ideation AWARD: $21,000 USD | DEADLINE: 1/15/15 | ACTIVE SOLVERS: 20 | POSTED: 12/15/14 1. The Challenge and qualification for the award Major depressive disorder (MDD) is a debilitating psychiatric disorder with about 20 million prevalent cases in the United States. Various antidepressants are available for treatment of patients suffering from MDD, however, about 50% of MDD patients do not respond adequately to initial treatments. Recent evidence shows that ketamine administered to patients with treatment resistant depression has resulted in marked improvement within hours of treatment. Boehringer Ingelheim (the Seeker) desires a working hypothesis for ketamine’s mechanism of action and sustained antidepressant effect. The submitted solutions will be considered for the award. There will be a guaranteed award for at least one submitted solution. The total payout will be $21,000, with at least one award being no smaller than $12,000 and no award being smaller than $3,000. 2. Additional application for Research Funding In addition to consideration for the award for the submitted Solutions, Solvers with appropriate qualifications and expertise having access to a suitable research laboratory and equipment can apply for research funding (“Research Funding”) to execute a research plan that is proposed in the Solution. The requested funding should not exceed a funding period of 2 years and a total budget of $200,000. The selection of candidates for Research Funding will be conducted after completion of this Challenge, and will require the submission of additional information. The decision to fund research will be at the discretion of the Seeker.   [更多]

可使生物降解的长效制剂微胶囊技术是一种药物控释技术。在授控的较长的一段时间药物缓慢释放。在过去的二十年中，武田公司已经完善了其专有技术，即具有微胶囊的长效制剂，能在人体的6个多月保持血药浓度。武田希望能有一种技术，即在确定的治疗药物，使用缓释长效制剂微胶囊技术能在任何人体组织上定向使用。具体如下：{https://www.innocentive.com/ar/challenge/9933674} AWARD: varies | DEADLINE: 1/26/15 | ACTIVE SOLVERS: 28 | POSTED: 12/10/14 Depot formulation using a biodegradable microcapsule is one technique for the controlled delivery of pharmaceuticals. The drug is slowly released over an extended period of time in a controlled manner. During the past two decades, Takeda has perfected its proprietary technology, which features a microcapsule depot formulation that maintains drug plasma levels for more than 6 months in humans. Takeda wishes to identify therapeutic agents that will benefit from sustained release through depot formulation using microcapsule technology. This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by the Seeker with a goal of establishing a Takeda funded collaborative partnership. A finder’s fee of $3,000 will be offered at the Seeker’s sole discretion to submission(s) that provide contacts which meet the criteria of the Challenge. Source: InnoCentive Challenge ID: 9933674 Challenge Overview Takeda is well known for its superior depot formulation using microcapsule technology. Controlled sustained release of drugs is achieved using either PLGA (poly-lactic-co-glycolic acid) or PLA (poly-lactic acid) polymer to make microspheres. This core technology is capable of producing injectable formulations that are biodegradable and release drugs over a period of weeks to months. By formulating drugs using this best-in-class approach, Takeda hopes to apply their microcapsule technology to improve the efficacy and safety of known therapeutics compared to the existing administration methods, while providing alternative treatment options to patients with unmet medical needs. In other words, Takeda makes this   [更多]

湿疹是一种慢性皮肤疾病，包括炎症，红肿，痒。许多非处方药品都是从干燥的角度来治疗湿疹的，南昌我们需要处方药物，减轻瘙痒和炎症的症状。现在寻求开发一种用于治疗湿疹的新的解决方案。具体如下：（https://www.innocentive.com/ar/challenge/9933668?challenge=9933668） TAGS: Chemistry, Requests for Partners and Suppliers, Life Sciences, Ideation AWARD: $15,000 USD | DEADLINE: 1/31/15 | ACTIVE SOLVERS: 55 | POSTED: 12/09/14 Eczema is a term that refers to a group of chronic skin conditions that involve inflammation, irritation, and itch. Many over-the-counter products are marketed to persons with eczema for the purpose of gaining relief from the dry, itchy rash. Flare-ups require prescription medications that alleviate the symptoms of itch and inflammation. The Seeker is looking to develop novel solutions for the treatment of eczema. This is an Ideation Challenge with a guaranteed award for at least one submitted solution. Source: InnoCentive Challenge ID: 9933668 Challenge Overview Eczema is a general term for all types of dermatitis. The etiology of eczema remains unknown, although there is evidence to suggest that the cause may be hereditary or linked to environmental triggers. People try many things to treat their eczema and these include over-the-counter remedies, prescription medications, and alternative therapies. Common complaints about these treatments stem from the lack of effectiveness in providing symptom relief. Topical corticosteroids and calcineurin inhibitors are widely used to effectively alleviate itch and inflammation, however, prolonged and inappropriate use can cause permanent changes to the skin such as skin thinning. Therefore, eczema treatment remains an unmet medical need. The Seeker is an independent, research-based pharmaceutical company that desires novel ideas for molecules, which are targeted for other diseases, but may also prove to be beneficial for eczema patients. This is an Ideation Challenge, which has the following unique features: There is a guaranteed award. The awards will be paid to the best   [更多]

距离报名截止还有355天 【基本信息】 需要 受试者类型 ： 健康受试者 性 别 ： 不限 婚 姻 状 况 ： 不限 适 应 专 业 ： 药物适应症： 易感冒人群 招 募 人 数： 500人 试验起止日期 ： 2014-10-01 -- 2015-12-05 报名截止日期 ： 2015-12-01 补 偿 金 ： 面议 【项目描述】 生物提取物，附加与鞋垫内层，通过长期穿戴，起到极好的抗感冒效果，适合任何人群，尤其适合体 弱的中老年人，未发现任何副作用。其机理通过足底穴位药理作用。有效率99%，一双鞋垫有效期3到6 个月。13180059226 【入选标准】 身体正常的，易感冒人群。 【排除标准】 儿童、孕妇 【研究中心列表】 石家庄 石家庄市正定生物化工研究所 【联系方式】 联系人 ： 魏新 手 机 ： 13180059226   [更多]

距离报名截止还有325天 【基本信息】 需要 受试者类型 ： 健康受试者 性 别 ： 女性 婚 姻 状 况 ： 不限 适 应 专 业 ： 药物适应症： 健康志愿者 招 募 人 数： 24人 试验起止日期 ： 2014-11-04 -- 2016-01-01 报名截止日期 ： 2015-11-01 补 偿 金 ： ￥3000 【项目描述】 试验日期：2014年 11月 20日～2015年 1月 30日，实验分为两个周期，两次服药间隔为14天。每一周 期的周五晚上开始入住试验病房，周六全天在试验病房，周日早上采血后离开试验病房，后周一至周六 每天早上到病房采血一次。其他时间自由不限，无需待在医院。 六、志愿者权利 1、知情权：将在“知情同意书”中作出详尽的书面说明，可向研究者详细咨询； 2、隐私权：您的隐私将得到保护； 3、体格检查、入住试验病房期间的餐饮均免费； 4、完成整个试验，您将获得营养补偿3000元/人； 5、本药物临床试验本着自愿的原则，试验过程任何阶段可自由离开。 【入选标准】 志愿者入选一般条件： l女性，年龄18～45岁； l体重45 kg以上，体重指数[BMI=体重(kg)/身高(m)2]在19~24 kg/m2范围内； l研究者根据全面的体格检查，实验室检查，12导联心电图和生命体征检查判定为健康受试者； l没有生育计划的受试者；手术绝育者（至少筛选前3个月）；或者同意从筛选期到研究结束后6个月采 用非药物方式进行安全避孕； l无器官疾病史和药物过敏史者； l非药物滥用者； l非烟酒嗜好者； l2周内无使用处方药或OTC药物，或者中成药者； l知情同意，并签署知情同意书； l能与研究者良好沟通，遵从整个研究的要求； l愿意并且能够遵从试验要求，并愿意按照要求入住临床试验病房。 【排除标准】 女性，年龄18～45岁； l体重45 kg以上，体重指数[BMI=体重(kg)/身高(m)2]在19~24 kg/m2范围内； l研究者根据全面的体格检查，实验室检查，12导联心电图和生命体征检查判定为健康受试者； l没有生育计划的受试者；手术绝育者（至少筛选前3个月）；或者同意从筛选期到研究结束后6个月采 用非药物方式进行安全避孕； l无器官疾病史和药物过敏史者； l非药物滥用者； l非烟酒嗜好者； l2周内无使用处方药或OTC药物，或者中成药者； l知情同意，并签署知情同意书； l能与研究者良好沟通，遵从整个研究的要求； l愿意并且能够遵从试验要求，并愿意按照要求入住临床试验病房。 【研究中心列表】 杭州 浙江仙琚制药股份有限公司 【联系方式】 联系人 ： 李 手 机 ： 18368027319   [更多]