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　本人需要左氧针剂灭菌温度变更补充申请资料，如果有的人请与我联系。   [更多]

寻依折麦布杂质结构式（订金已支付给药智网，请踊跃投标） 要求提供依折麦布中杂质中的结构式，要求不得有缺漏及错误，具体代码及类别如下： 联系QQ：1667479459   [更多]

茄尼醇纯品为白色粉末或蜡状固体，通常含有少量杂质而呈淡黄色。茄尼醇易溶于乙醚、丙酮、烃类等有机溶剂而不溶于水，其对紫外光呈非选择性吸收，无旋光性。其熔点较低，为32-33℃ 。茄尼醇是一种重要的医药中间体，是泛醌类药物中间体不可替代的成分，是合成维生素K的侧链和辅酶Q10以及合成抗溃疡药物、抗癌药物不可替代的天然原料。我公司目前对市场进行调研， 95%以上茄尼醇需求较大。正着手准备从烟草中提取茄尼醇的实验，开展高纯度茄尼醇分离纯化研究。 要求：茄尼醇分离纯化工艺达到中试水平，含量达到95%以上，成本控制在2500元/kg以下。质量符合企业内控标准。 合作方式：技术合作或者技术转让等方式解决 重庆恒星生物技术有限责任公司   [更多]

有没在药企做持续改进、精益生产、IE的同行，提供下药厂精益生产项目、持续改进项目案例等，及精益生产实施计划、保障措施等等全套资料   [更多]

Disulfiram 我想要一份USP版本的分析单   [更多]

这是一项关于寻找材料加工技术的任务，要求是要用纳米团簇生产含能材料，这个技术的重点要是在一个可控的过程中进行，要有稳定的空气和粒子率增加一致。 这个任务需要提交一份书面的建议书 Energetic Core-Shell Nanocluster Production AWARD: $20,000 USD | DEADLINE: 11/19/12 | ACTIVE SOLVERS: 116 | POSTED: 9/19/12 Source: InnoCentive Challenge ID: 9932739 Type: Theoretical-licensing Detailed Description & Requirements Background Core-shell nanoclusters are groups of atoms of usually 2 materials in an arrangement such that one material, in the center, is the “core” of atoms which is coated with atoms of another material or the “shell”. These clusters contain from 10’s to millions of atoms and aggregates are in the nanometer range (~5 to 1000 nm). An example would be a core of Fe atoms and a shell of Au atoms. The Fe would not be stable as it would oxidize quite rapidly on its own, but the gold shell protects it from oxidation, yet the small clusters still exhibit magnetic behavior. This is the most simplistic core-shell and there are many different arrangements with multiple materials and multiple shells and the Solvers can look at the references attached for more information. Nanoclusters are unique as they exhibit properties different from bulk materials which are many times cluster size dependent. Of particular interest are highly energetic materials such as mixtures of metals and metal oxides. As nanoclusters, these materials have increased reactivity, because mass transport is removed as a barrier between fuel and oxidizer (i.e. all atoms are in intimate contact). Using the classic thermite reaction, an Al core of atoms could be coated with Fe Oxide which would protect the Al from oxidation. When ignited as nanoclusters the reaction rate would be increased over the bulk materials. The Challenge The Seeker is interested in material processing technologies for the production or fabrication of nano-scale core-shell cluster energetic materials with particle diameters between 5 and 25 nm. This process has been done in   [更多]

任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。 Seeking Bicyclic Aminoketones AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12 Source: InnoCentive Challenge ID: 9932910 Type: RTP Detailed Description & Requirements Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references: Synthesis, 1, 1979, 50. Synthesis, 3, 2010, 493. Tetrahedron, 68 (4), 2012, 1286. J. Organic Chem, 73 (6), 2008, 2114. J. Med. Chem, 37 (18), 1994, 2831. More specifically, the Seeker is looking for compounds that meet the following Requirements: Structure: FeatureRange StructureA bicyclic aminoketone as shown in the structures above. Elements in R and A groupsR = H, Me, or protecting group (preferably Boc) A = A 1-3 membered linker where one atom may be N, O, or S Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F. Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups. Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle. Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider   [更多]

这项任务要要求设计一个自动化的，高通量的仪器 ， 可以定量地和可重复地测定的油水乳化液的分离。 这个任务需要提交一份书面建议书。 An Instrument for Quantitative, Reproducible Characterization of Water/Oil Emulsions AWARD: $30,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 508 | POSTED: 8/15/12 Source: InnoCentive Challenge ID: 9933086 Type: Theoretical-IP Transfer Detailed Description & Requirements The presence of emulsions in oil operations is common and generally undesirable. Crude oil emulsions typically form due to the presence of naturally occurring emulsifying agents (asphaltenes, resins, etc.) in crude oil. The high cost associated with transportation and corrosion of equipment is one of the problems caused by the presence of water in the crude oil. Therefore, oil dehydration is required, which is often achieved through chemical treatment using demulsifiers. While the Seeker has identified ~200 liquid “demulsifier” agents, compounds that in amounts of ~100-500 ppm can aid in the resolution of the water and oil phases, they lack a quantitative and reproducible assay for determining demulsifier effectiveness at resolving the emulsion. Currently, the Seeker performs a “bottle test” in which they add ~15-100 mL of the emulsion into a bottle, add the different demulsifiers, shake, and then visually observe which bottles show the best phase separation. This assay clearly relies on visual detection by a trained observer and is not nearly as quantitative or reproducible as the Seeker desires. Results from a bottle test with the same emulsion and three different demulsifiers are shown below. The bottle on the left has clearly not been resolved into two distinct phases. While the middle bottle shows significant improvement, careful inspection of the phase boundary shows a slight amount of oil contaminating the water layer and a slightly undefined interface. Finally, the bottle on the right shows an optimally resolved two-phase system with a very clear oil/water phase boundary. Important Note:   [更多]

RT，要求上述所罗列项目包括了菌种、发酵工艺、后提取精制工艺及相应的参数指标。   [更多]

需求描述： 口腔硬组织很容易聚集牙垢和牙菌斑。需要确定经证明能防沉积并轻松去除沉积物的技术和产品。 我们寻求： 比传统口腔护理产品(牙膏和漱口水)防附着性能更强的产品 ¨ 益处能持续一段时间(距离下一次刷牙)且比目前市场上的口腔护理产品更优越 ¨ 技术/产品必须与钠和氟化亚锡相容 ¨ 防附着机制必须不影响牙釉质吸收氟 所关注的益处 预防牙菌斑 预防牙垢 预防牙结石 ¨ 产品形式可包括 牙膏(液态) 漱口水(液态) 凝胶(非液态) ¨ 最好是具有下列特征的技术： 从软硬组织沉积、留存并释放物质的技术 所有基于液态的口腔护理制剂均有性能、稳定性和相容性相关数据 有相当于适当阴性对照组的性能数据(技术/消费者/临床) 有能证明和量化益处的独特能力 人体安全性已得到确认或材料得到美国公认安全认证(GRAS) 使用产品后有明显清洁感 获得专利保护 我们对下列技术不感兴趣： 不受强有力知识产权保护的技术 需要广泛的安全许可或监管部门批准的技术 稿件提交网址：宝洁联系与发展部http://www.pgconnectdevelop.cn   [更多]