For more than two centuries, vaccines been used to generate protective immunity against diseases. Vaccines generally contain attenuated viruses, inactivated viruses/toxins, or pathogenic subunits. Nucleic acid-based vaccines induce a cell-mediate immune response without the presence of adjuvants, thus providing an advantage over subunit vaccines; they are also incapable of infecting the host, so they are a safer alternative compared to attenuated versions. The Seeker is searching for formulation improvements with a focus on RNA replicon vaccines.
两个多世纪以来，疫苗一直用于产生针对疾病的保护性免疫。疫苗通常含有减毒病毒，灭活病毒/毒素或致病亚单位。基于核酸的疫苗在不存在佐剂的情况下诱导细胞介导的免疫应答，因此提供优于亚单位疫苗的优势; 它们也无法感染宿主，因此与减毒版相比，它们是更安全的替代品。搜索者正在寻找配方改进，重点是RNA复制子疫苗。
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