任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。
Seeking Bicyclic Aminoketones
AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12
Source: InnoCentive Challenge ID: 9932910 Type: RTP
Detailed Description & Requirements
Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule).
Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references:
Synthesis, 1, 1979, 50.
Synthesis, 3, 2010, 493.
Tetrahedron, 68 (4), 2012, 1286.
J. Organic Chem, 73 (6), 2008, 2114.
J. Med. Chem, 37 (18), 1994, 2831.
More specifically, the Seeker is looking for compounds that meet the following Requirements:
Structure:
FeatureRange
StructureA bicyclic aminoketone as shown in the structures above.
Elements in R and A groupsR = H, Me, or protecting group (preferably Boc)
A = A 1-3 membered linker where one atom may be N, O, or S
Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F.
Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups.
Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle.
Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider
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