任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。 Seeking Bicyclic Aminoketones AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12 Source: InnoCentive Challenge ID: 9932910 Type: RTP Detailed Description & Requirements Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references: Synthesis, 1, 1979, 50. Synthesis, 3, 2010, 493. Tetrahedron, 68 (4), 2012, 1286. J. Organic Chem, 73 (6), 2008, 2114. J. Med. Chem, 37 (18), 1994, 2831. More specifically, the Seeker is looking for compounds that meet the following Requirements: Structure: FeatureRange StructureA bicyclic aminoketone as shown in the structures above. Elements in R and A groupsR = H, Me, or protecting group (preferably Boc) A = A 1-3 membered linker where one atom may be N, O, or S Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F. Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups. Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle. Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider racemates, but will be particularly interested in compounds that can be prepared as single enantiomers. Molecular Weight< 350 Reactive Functionalities to be AvoidedAcid chlorides, anhydrides, a,b-unsaturated ketones, alkyl halides, etc. Purity: > 95% (1H-NMR) Novelty: Must not be commercially available. Stability: In all cases the compounds should have an expected shelf life of at least six months and should be safe and stable through the shipping process. Amount: A minimum of 1.0 g of each compound is required. The Seeker intends to award multiple Solvers for each of their qualifying submissions. Please go to our Upload Your Libraries Challenge if you would like to have your list of compounds for this Challenge considered for future Challenges, or if you would like to upload your entire library of compounds for consideration in future Challenges. Project Criteria By the deadline, please submit the following: List of structures that comply with the Requirements listed above. Solvers are encouraged, but not required, to use the attached DB file template. Each structure should: Be presented, ideally, in one of the following formats: ISIS database (DB) or SDF. Be presented, alternatively, in SMILES, ChemDraw, Word Doc, or Excel file formats. InnoCentive has identified and obtained permission to advertise to our Solvers two FREE programs for creating SDF files: ACDLabs Chemsketch [http://www.acdlabs.com/resources/freeware/chemsketch/] LICSS [http://code.google.com/p/excel-cdk/] – Excel-based freeware Have a unique sourceidentification code (Example: "Joe’s Compound 001", "Joe’s Compound 002", etc.) Have a comment if the compounds are in stock (“in stock”), previously made but must be resynthesized (“resynthesized”), or if the 3 month period will be needed for synthesis (“3 months”). Have a comment about how much of the compound is, or could be, prepared. Document with contact information for shipping: Key contact person for this Challenge, including phone number and email address. Company name, shipping address. Following the submission deadline for this Challenge, the following steps will take place: Structure selection (~ 1 month) After the Challenge deadline the Seeker will then review the list of structures, and within one month of the Challenge Deadline, decide which structure, if any, to purchase. InnoCentive will notify Solver(s) by email as to which structures have been selected for purchase. Compound retrieval or synthesis (< 3 months) Solvers shall then confirm by email as to which of the following options they choose: Immediate shipping of selected compounds: Solvers who have selected compounds ready (on the shelf) can request immediate shipping. Synthesis of selected compounds: Solvers who need to synthesize selected compounds can request up to three months to find or prepare the selected compounds. Compound Shipping (~ 1 months) Solver(s) will then use their own packaging materials to ship a material sample of each requested structure to the Seeker. Solvers should not send samples of the molecules to InnoCentive. Each sample: Must contain at least 1.0 grams of each structure selected. Must meet the Purity Requirement listed above. Must be accompanied by documentation of its purity (preferably 1H-NMR & LC-MS). Compound evaluation and payout (~ 1 month) After receipt of the samples, the Seeker may carry out analysis on each sample to determine if the forwarded samples meet the purity requirement listed above. For each sample that is accepted, the Seeker will pay the Solver the Initial Transfer Fee of USD 1,500 per 1.0 g of compound plus reasonable shipping expenses. For each accepted submission, the Solver will be expected to grant the Seeker a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). This is explained in detail in section 4(d) of the InnoCentive Challenge-Specific and Material Transfer Agreement. If the Seeker determines that they desire exclusive rights to any of the Solver’s intellectual property associated with the Solution, an additional payment will be made to the Solver of an amount to be determined through direct negotiation between the Seeker and Solver. This is explained in detail in section 4(e) of the InnoCentive Challenge-Specific and Material Transfer Agreement. This Challenge is targeting Solvers who have matching compounds already made (on the shelf) or Solvers who are prepared to synthesize selected compounds within the provided timelines. Solvers who have selected compounds on the shelf can request immediate shipping and payout. Solvers who elect to prepare selected compounds will have up to three months to do so. Solvers who consider synthesis of selected structures shall be aware of the timelines. The Seeker wants to receive the selected compounds within the timelines provided above and will not allow for additional time to complete synthetic efforts.

这是一项关于寻找材料加工技术的任务，要求是要用纳米团簇生产含能材料，这个技术的重点要是在一个可控的过程中进行，要有稳定的空气和粒子率增加一致。 这个任务需要提交一份书面的建议书 Energetic Core-Shell Nanocluster Production AWARD: $20,000 USD | DEADLINE: 11/19/12 | ACTIVE SOLVERS: 116 | POSTED: 9/19/12 Source: InnoCentive Challenge ID: 9932739 Type: Theoretical-licensing Detailed Description & Requirements Background Core-shell nanoclusters are groups of atoms of usually 2 materials in an arrangement such that one material, in the center, is the “core” of atoms which is coated with atoms of another material or the “shell”. These clusters contain from 10’s to millions of atoms and aggregates are in the nanometer range (~5 to 1000 nm). An example would be a core of Fe atoms and a shell of Au atoms. The Fe would not be stable as it would oxidize quite rapidly on its own, but the gold shell protects it from oxidation, yet the small clusters still exhibit magnetic behavior. This is the most simplistic core-shell and there are many different arrangements with multiple materials and multiple shells and the Solvers can look at the references attached for more information. Nanoclusters are unique as they exhibit properties different from bulk materials which are many times cluster size dependent. Of particular interest are highly energetic materials such as mixtures of metals and metal oxides. As nanoclusters, these materials have increased reactivity, because mass transport is removed as a barrier between fuel and oxidizer (i.e. all atoms are in intimate contact). Using the classic thermite reaction, an Al core of atoms could be coated with Fe Oxide which would protect the Al from oxidation. When ignited as nanoclusters the reaction rate would be increased over the bulk materials. The Challenge The Seeker is interested in material processing technologies for the production or fabrication of nano-scale core-shell cluster energetic materials with particle diameters between 5 and 25 nm. This process has been done in the lab at very small quantities (1 – 2 ?g/hour), but there is interest in a production capability or a research method that could scale up to at least 1g/hour. Another important part of this effort is to make the energetic material air stable as well. There are several possible approaches (including, but not limited to): aerosol condensation methods colloidal wet-chemistry based assembly techniques Atomic Layer Deposition (ALD) process Superfluid Helium Droplet Synthesis (SHeDA) process fluidized bed reactors self-assembly condensation solid matrices sonochemistry gas-phase co-condensation We are looking for either: An existing production method that can be used to mass produce a stable metal-metal or metal - metal oxide energetic material (e.g. Ni-Al, Al-CuO) or An existing production method that can be modified as above or A research method that could be scaled up to a production method as above (identifying any limiting factor for scalability). Problems Identified The problems that have been identified in the above processes are: The ALD commercialization process is limited by not being able to maintain the core-shell particles sizes small (~ 10 nm) as the production rates increase. The SHeDA method is flexible in producing core-shell energetic particles of size 1-10 nm of essentially any combination of reactants. The problem is that it only produces material at a rate of ~ 1-2 ?g/hour. Some of those processes that do scale up; have issues with producing clusters that exhibit core-shell (onion-like) configurations. A third layer to prevent agglomeration or passivation is undefined, but we are also looking for a process that has the potential to put in a third insulating layer. This could, perhaps, be something like a graphene film, or in the case of a metal core, a less reactive metal, or even an inert polymer. We are looking for a technology that may be flexible in its ability to incorporate different materials. It is important that the composition, insulating layer, binder, or morphology is controllable. The final product will likely be agglomerates of the core-shell nanoparticles of the micron scale. This morphology is not as critical and need not be defined. The consistency (size) of the clusters from this process should be able to keep the composition of the materials within approximately 25%. That is, particles of interest are in the 5 to 25 nm diameter, but whatever the size made, must be consistent (e.g. 10 nm +/- 2.5 nm). The ratio of materials (e.g. Fe2O3 to Al) must also be controlled near stoichiometric amounts. Any proposed solution should address the following Technical Requirements: Provide a production method capability to produce metal-metal and metal-metal oxide, nano-scale, core-shell cluster energetic materials with consistent (+/- 25%) particle diameters in the range of 5-25 nm. The method must produce at a 1g/hr rate with the ratio of the compositions near stoichiometric. The production method should control the composition, insulating layer, binder, and morphology. Final products must be stable in air. The proposed system should offer the Seeker client “freedom to practice” and be available for licensing. There should be no third party patent art preventing the use of specific equipment and materials for their commercial application. Project Criteria This is a Theoretical Challenge that requires only a written proposal to be submitted. The submitted proposal should include the following: Detailed description of a method (using Ni-AL or Al-CuO as examples of metal-metal, metal-metal-oxide combinations) that could meet all of the above Technical Requirements. Rationale as to why the Solver believes that the proposed method will work. This rationale should address each of the Technical Requirements described above and should be supported with any relevant examples, data and references. This should include both the materials and process. This rationale will be very important in the evaluation of solutions. Any data that could back up the claim that the production method would scale up to the required 1g/hr. List any limitations of where this production method could not scale up further. Also list, if known, other energetic metal-metal or metal-metal oxide materials that this process would not work with. Identification of any safety factors that make the final product unstable. If a research technique, then need identify the limiting factors for production scalability and describe why this approach may succeed. Description of what would be required to make this final product stable in air as well as triggers would make the final product unstable (e.g. heat, pressure, shock, electromagnetic pulse). If known, identify a production company that could or might be willing to manufacture the final product using the suggested production method. The proposal should not include any personally identifying information (name, username, company, address, phone, email, personal website, resume, etc.) The Challenge award will be contingent upon evaluation of the proposal by the Seeker. To receive an award, the Solvers will not have to transfer their exclusive IP rights to the Seeker, instead, they will grant to the Seeker non-exclusive license to practice their solutions. Other arrangements might be considered, if a license cannot be granted.

寻找一个有经验的会不锈钢金属蚀刻技术的合作伙伴。要求该合作伙伴精通蚀刻工艺的精度控制，并且具备大规模的生产能力，能在未来起到重要作用。 这是一项寻找合作伙伴的任务，要求提交一份关于建立合作伙伴关系的书面建议书。 Precise Chemical Metal Etching AWARD: varies | DEADLINE: 11/09/12 | ACTIVE SOLVERS: 6 | POSTED: 9/25/12 Source: InnoCentive Challenge ID: 9933182 Type: eRFP Detailed Description & Requirements Background The Seeker has a product whose parts are made by the precise chemical etching of thin Stainless Steel sheets. Stainless steel etching is not very common for precision parts because the requirements are usually too strict for the etching techniques due to underetching. The Seeker has pushed the limits of the metal etching process and has developed processes that potentially work for their application. The Seeker is now looking for partners who can do precision SS etching to potentially become suppliers of parts that will number in the hundreds of millions per year in total. The partner will have developed their own specialized etching technique to make the structures required. The Challenge and Opportunity We are seeking companies which are specialized in chemical metal etching of stainless sheet steel (~200 – 300 ?m thickness). The desired partner should be able to produce the structures on the template below using an etching technique. (Note: For easier viewing, a larger copy of the drawing is attached to this Challenge.) We do not expect the Solvers to actually produce the template structures for this Challenge, but show that they have the skills and equipment to potentially produce the structures. If selected as a potential partner by the Seeker after the Challenge, then you will be asked to produce the structures directly for the Seeker. The template is not the actual part of interest, but the Seeker is confident if you can reproduce the template, then it will translate to making the part. Figure 1- Etching Structure Template It should absolutely be clear that when using an etching technique, the edges are not rectangular and that the channel walls are not vertical and straight, but that there occurs a so called “underetching” which leads to a more drop like roundish profile of the channels. Below is a diagram showing the underetching principle. Figure 2- Example of underetching A good indicator for the precision is the extent of underetching and how close two channels can be placed without eliminating the parting walls. An excellent control of underetching is required to make the structures as drawn. Technical Requirements Potential partners will be those deemed to offer the highest probability of meeting the following requirements: The partner should be able to produce the template attached on stainless steel sheet of 200 to 300 ?m thickness. Note: you do not need to physically produce the template for the purposes of this Challenge, but you will be asked to produce it later, if chosen by the Seeker. The template should be produced by any etching technique such as a dry or wet film technique. The etching technique must be amenable to mass production (millions of parts/year). It would be preferable if the etching could be performed on a roll of stainless steel sheet (i.e. reel to reel), but other arrangements might be acceptable if mass production can be accomplished. The maximum cost of the technique is not defined for this Challenge; however low cost of production will be a consideration when choosing between collaboration partners. Requirements for a Partner: (not all absolutely required, but preferred) The partner(s) should be skilled and have experience in the precision etching of stainless steel sheet. The partner should have some experience working in a mass production type environment.. The partner should be able to work closely with the Seeker in pursuing and improving the technology. Partners who are selected by the Seeker may be engaged on a project and produce parts for the Seeker under future contract. Project Criteria This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by the Seeker with a goal of establishing a collaborative partnership. The submission (usually about 5 pages) should include the following: The Etching Technique A discussion of your etching technique and the process you would use to make the template. Of particular interest is if it is a dry or wet etching technique and how thick is the lacquer layer. Also, how will the technique work in mass production (e.g. can you produce reel to reel?). Proprietary information can be left out, if necessary, as long as you can convince the Seeker your technique can work to produce the template. A brief discussion of your capabilities and prior experience as related to the precision etching of stainless steel. You should show examples of your work, if possible, and anything that would convince the Seeker of your ability as a partner.You should also discuss potential production capacity and mass production processes. A discussion of your ability to control etching (and underetching) precisely. General Information about the Submitter(s) including: Organization/Company/Universityname and address (including website, if available); The key contact person for this Challenge (including phone number and email address). (Note: For most Challenges, Solvers are not allowed to include personal contact information; however, for an eRFP Challenge, it is required.) How eRFP Challenges work: In contrast with other types of Challenges, there is no a predetermined Award for eRFP Challenge. The potential award would be a contract with the Seeker to conduct collaborative work and/or to provide materials and services to the Seeker in the future. After the deadline, all proposals will be forwarded to the Seeker for evaluation. If the Seeker identifies the Solver as a potential partner, they will contact the Solver directly to make the attached template as proof of the technique. The Seeker may request a more detailed proposal after further discussions. Neither party is obligated to work together until a mutually agreeable contract is agreed upon.