• 2019-11-08

    1、Nimesulide - a non-steroidal anti-inflammatory drug, a preferential cyclooxygenase-2 inhibitor 【出处】Vutreshni bolesti. 2000;32(1):33-6. 2、Bioequivalence study between two slow release batches ofindapamide SR 1.5 mg with different dissolution pro- files after repeated oral administration over 7 days in 12 healthy volunteers: a randomised double blind cross over study. Fulmer Hall, UK: Servier, 1993. Report No.: NP 910 3、Schiavi P, Jochemsen R, Hiley M, et al. Pharmacokinetics ofslow and immediate release formulations of indapamide after single oral administration under fasting conditions and after food, in healthy volunteers. Eur J Drug Metab Pharmacokinet 1996; Spe- cial Issue: 42 4、找一篇97年的政策法规文件,标题:国家医药管理局国药字(97)253号文件 5、Higuchi T, Murasaki M, Kamijima K. Clinical evaluation of duloxetine in the treatment of major depressive disorder. Jpn J Clin Psychopharmacol 2009;12:1613-1634

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  • 2019-10-16

    EP10.0: 1. 昔萘酸沙美特罗Salmeterol Xinafoate 2. 对氨基水杨酸钠Sodium Aminosalicylate Dihydrate 3. 亚胺培南Imipenem monohydrate 4. 西司他丁钠Cilastatin sodium 5. 制霉菌素Nystatin 6. ω-3 脂肪酸甘油三酯Omega-3-Acid Triglycerides 7. 噻托溴铵一水合物Tiotropium Bromide Monohydrate 8. 硫酸沙丁胺醇Sulbutamol Sulphate 文献: 1、Preventative approaches for neurophathy in diabetes with Alpha-lipoic Acid 2奥硝哩 在人体 内的代谢与排泄研究 杜江 波 ” , 尤 天庚 ’ , 陈笑艳 ’ , 钟 大放 ” 1. 中国科学院上海药物研究所 , 上海 2 0 1 2 03 2 . 上海东方医院 , 上海 2 0 01 2 0

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  • 2019-10-16

    1、Ophthalmic viscosurgical devices Article· Literature Review in Current Opinion in Ophthalmology 19(1):50-4 · February 2008 with 82 Reads DOI: 10.1097/ICU.0b013e3282f14db0 · Source: PubMed 2、Lancet Psychiatry. 2019 Mar;6(3):211-224. doi: 10.1016/S2215-0366(18)30511-X. Epub 2019 Feb 18. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Huang Y1, Wang Y2, Wang H3, Liu Z4, Yu X4, Yan J5, Yu Y6, Kou C6, Xu X7, Lu J7… PMID:30792114 3、Prevalence of myopia in local and international schools in Hong Kong. 4、Effects of different concentrations of atropine on controlling myopia in myopic children. 5、Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys 6、Effects of different concentrations of atropine on controlling myopia in myopic children. 7、Use of mechlorethamine gel in patients diagnosed with mycosis fungoides cutaneous T-cell lymphoma (MF-CTCL): “Real-world” experience from the Prospective Observational Study (PROVe) 8、Safety and effectiveness of tolvaptan administration after total arch replacement Yasunori Iida, MD, PhD, Akihiro Yoshitake, MD, PhD, Hideyuki Shimizu, MD, PhD 9、The role of tolvaptan administration after cardiac surgery: ameta-analysisIoannis Bellos MD , Dimitrios C. Iliopoulos MD, PhD ,Despina N. Perrea MD, PhD 10、Comparative bioavailability and in vitro in vivo correlation of two sustained release brands of theophylline: tablets and pellets.Tulain U, Ur-Rahman N.Pak J Pharm Sci. 2008 Apr;21(2):131-8. 11、Relative bioavailability and bioequivalence study of theophylline sustained release formulations. Vergin H, Mahr G, Winterhalter B, Wigand R.Arzneimittelforschung. 2003;53(9):635-9. 12、Use of mechlorethamine gel in patients diagnosed with mycosis fungoides cutaneous T-cell lymphoma (MF-CTCL): “Real-world” experience from the Prospective Observational Study (PROVe) 13、journal of medicinal chemistry 2004,47,530 14、Gupta AK, Ryder JE, Lynch LE et al. The use of terbinafine in the treatment of onychomycosis in adults and special populations: areview of the evidence. J Drugs Dermatol 2005; 4:302–8. 15、Jennings MB, Pollak R, Harkless LB et al. Treatment of toenail onychomycosis with oral terbinafine plus aggressive debridement:IRON-CLAD, a large, randomized, open-ultielabel, mcnter trial. J Am Podiatr Med Assoc 2006; 96:465–73. 16、drug stability:principles and practices 17、Oseltamivir oral suspension and capsules are bioequivalent for the active metabolite in healthy adult volunteers.Lennon S1, Barrett J, Kirkpatrick C, Rayner C. 18、terrahedron asymmetry 1999, 10(14), 2639-2642 19、J. Chem. Soc., Perkin Trans. 1, 1994, 2927-2930 20、European journal of organic chemistry 2009, 6160-6171 21、Japanese guideline for the management of hyperuricemia and gout: second edition. Yamanaka H; Japanese Society of Gout and Nucleic Acid Metabolism.Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1018-29. doi: 10.1080/15257770.2011.596496.PMID: 22132951 22、Isolation and Validation of Anti-B7-H4 scFvs from an Ovarian Cancer scFv Yeast-Display Library. 23、Preparation and characterization of monoclonal antibody against human B7-H4 molecule. 24、Propafenone quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry in a bioequivalence study 25、Linagliptin fixed-dose combination with metformin is bioequivalent to co-administration of linagliptin and metformin as individual tablets. Buschke S, Ring A, Friedrich C, Metzmann K, Meinicke T. Int J Clin Pharmacol Ther. 2014 Jul;52(7):537-48. doi: 10.5414/CP201960. 26、Effect of food and tablet-dissolution characteristics on the bioavailability of linagliptin fixed-dose combination with metformin: evidence from two randomized trials. Metzmann K, Schnell D, Jungnik A, Ring A, Theodor R, Hohl K, Meinicke T, Friedrich C. Int J Clin Pharmacol Ther. 2014 Jul;52(7):549-63. doi: 10.5414/CP201961. 27、Absorption, Distribution, Metabolism and Excretion of Glucosamine Sulfate 28、Non-Submental Applications of Injectable Deoxycholic Acid: A Systematic Review Sung CT, Lee A, Choi F, Juhasz M, Mesinkovska NA J Drugs Dermatol [01 Jul 2019, 18(7):675-680] 29、The Use of Deoxycholic Acid for the Clinical Reduction of Excess Submental Fat in Indian Patients Shome D, Khare S, Kapoor R J Drugs Dermatol[01 Mar 2019, 18(3):266-272] 30、请帮忙查找文献:名称:塩原隆造、大平貴之、小野塚聰、河瀬斌.脳神経外科手術時の洗浄・灌流液の調査、検討 II.新薬と臨床2006;55(7):1040-133. 31、Send to Curr Med Chem. 2019;26(3):554-563. doi: 10.2174/0929867324666170817151954. MUC1 Story: Great Expectations, Disappointments and the Renaissance. 32、New Journal of Chemistry2018vol. 42# 17p. 14365 - 14385 33、Helvetica Chimica Acta1984vol. 67p. 906 - 915 34、The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis 35、60 Posaconazole vs. fluconazole as invasive fungal infection prophylaxis in China: a multicenter, randomized, open-label study. Int J Clin Pharmacol Ther. 2013 Sep;51(9):738-45. Shen Y, Huang XJ, Wang JX, Jin J, Hu JD, Yu K, Wu DP, Wang SJ, Yu L, Chen XQ, Liu T, Liang YM, Chen FP, Li Y, Shen ZX. 36、A Rapid, Solvent-Free Deprotection of Methoxymethyl (MOM) Ethers by pTSA; An Eco-Friendly Approach Author(s): Nanjan Pandurangan* . Journal Name: Letters in Organic Chemistry Volume 14 , Issue 4 , 2017 DOI : 10.2174/1570178614666170321103650 37、Griffiths, Gareth J.; Hauck, Michael B.; Imwinkelried, Rene; Kohr, Joerg; Roten, Conrad A.; Stucky, Gerhard C.; Gosteli, Jacques; Journal of Organic Chemistry; vol. 64; nb. 22; (1999); p. 8084 - 8089 38、Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro 39、J. Org. Chem.20127773348-3364 40、J. Org. Chem.20046951646-1651 41、Nalbuphine. A preliminary review of its pharmacological properties and therapeutic efficacy. 42、Drug and Alcohol Dependence Volume 14, Issues 3–4, February 1985, Pages 339-362 43、GlycosaminoglycansChemistry and Biology, 44、Chemistry and Biology of Heparin and Heparan Sulfate,请找下这2本书籍 45、Helvetica Chimica Acta; vol. 40; (1957); p. 1319,1327; 46、Journal of Medicinal Chemistry; vol. 34; nb. 4; (1991); p. 1314 – 1328; 47、Journal of Pharmaceutical Sciences; vol. 69; nb. 6; (1980); p. 707 - 710; 48、Synthetic Communications; vol. 10;nb. 12; (1980); p. 939 - 946 49、J Cardiovasc Med (Hagerstown). 2012 Jul;13(7):415-22. Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. 50、 Nephrology (Carlton). 2018 Sep;23(9):883-886. Tolvaptan alleviates excessive fluid retention of nephrotic diabetic renal failure unresponsive to furosemide. 51、Clin Exp Nephrol. 2014 Aug;18(4):655-61. Tolvaptan increases urine and ultrafiltration volume for patients with oliguria undergoing peritoneal dialysis. 52、Cytotoxicity and Cell Cycle Specificity of Homoharringtonine 53、Journal of the American Chemical Society; vol. 73; (1951); p. 5752,5756 54、Opportunities and Challenges of Multinational Pharmaceutical Enterprises in Transforming Pharmaceutical Market in China 55、Am J Cardiovasc Drugs. 2019 Feb;19(1):75-86. DAPT Plus Cilostazol is Better Than Traditional DAPT or Aspirin Plus Ticagrelor as Elective PCI for Intermediate-to-Highly Complex Cases: Prospective, Randomized, PRU-Based Study in Taiwan.

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  • 2019-10-15

    文献: 1、Journal of Organic Chemistry1961vol. 26p. 2507 - 2510 2、J Contemp Dent Pract. 2016 Dec 1;17(12):1009-1012.Rebamipide to Manage Stomatopyrosis in Oral Submucous Fibrosis.Baptist J1, Shakya S2, Ongole R1. 3、heart failure with preserved ejection fraction:types 1 and 2 ?10.1016/j.jchf.2018.12.017 4、Current status of research on infantile cholestatic liver disease in China: a visualization analysis Author(s): LIAO Qiong, WAN Chao-Min, ZHU Yu, YANG Xiao-Yan, SHU Min, Department of Pediatrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University 5、Diagnosis and differential diagnosis of infantile cholestasis disease Author(s): Dong Chen, Huang ZhihuaDong Chen: Department of Pediatrics, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China 6、In vitro dissolution and in vivo bioequivalence evaluation of two brands of isosorbide 5-mononitrate sustained release tablets.Kim YH1, Choi KS, Kam SH, Lee KH, Park JS 7、Evaluation of the bioequivalence and pharmacokinetics of two tablet formulations of isosorbide-5-mononitrate after single oral administration in healthy volunteers. Niopas I1, Daftsios AC, Nikolaidis N. 8、PK/PD analysis of Tebipenem Pivoxil (ME1211),a Novel Oral Carbapenem Antibiotic,in otolaryngological infections,a phase II clinical trial;(新型口服碳青霉烯类抗生素替比培南匹伏酯(ME1211)在耳鼻咽喉感染中的pk/pd分析,一项Ⅱ期临床试验) 9、PK/PD analysis of Tebipenem Pivoxil (ME1211),a Novel Oral Carbapenem Antibiotic,in otolaryngological infections,a phase II clinical trial;(新型口服碳青霉烯类抗生素替比培南匹伏酯(ME1211)在耳鼻咽喉感染中的pk/pd分析,一项Ⅱ期临床试验) 10、Trends in the Management of Acute Heart Failure Requiring Intensive Care Shirakabe A Kobayashi N, kazakh Matsushita M, Shibata Y -, Godah, Shigihara s", AsanKiuchit 11、Patient Selection for Tolvaptan Therapy Among Those With Chronic Kidney Disease and Heart Failure 12、Baumann; Butler; Deering; Mennen; Millar; Nanninga; Palmer; RothTetrahedron Letters1992vol. 33# 17p. 2283 - 22841: 2) NEt3 / 1) ethyl thiazolium catalyst / or with methyl thiazolium catalyst; 1) EtOH 2: 75 percent / pivalic acid / toluene; heptane; tetrahydrofuran / Heating 13、Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine. 14、文献:lack of bimodality in nifedipine plasma kinetics in a larger population of healthy subjects 15、The bioequivalence of two oral propafenone preparations]. [Article in German] Koytchev R1, Alken RG, Mayer O, Böhm R, Ellrich A, Waldner-Kölblin RG. 16、需要查询一篇文献,Biosimilars in allergic diseases.Ferrando M1, Bagnasco D, Braido F, Varricchi G, Canonica GW. 17、Expression and identification of recombinant mouse gene B7-H4 18、Org. Process Res. Dev.2012162262-268 19、36 Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia N Engl J Med 2007; 356: 348–59. Cornely OA, Maertens J, Winston DJ et al. 20、37 Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med 2007; 356: 335–47. Ullmann AJ, Lipton JH, Vesole DH et al. 21、FDA Approval is Not the End: Getting the Most Out of Taxol Elaine BlumeJNCI: Journal of the National Cancer Institute, Volume 85, Issue 3, 3 February 1993, Pages 181–182, https://doi.org/10.1093/jnci/85.3.181Published: 03 February 1993 22、3. Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index 23、The effect of sodium alginate on the antibacterial activity of chlorhexidine, gentamicin and ciprofloxacin 24、1.Tetrahedron Letters Volume 50, Issue 13, 1 April 2009, Pages 1438-1440 25、2.synthetic communications 1997, 27(11), 1819-1825 26、48 The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica. 2006 Aug;91(8):1068-75. Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B, Pastore D, Picardi M, Bonini A, Chierichini A, Fanci R, Caramatti C, Invernizzi R, Mattei D, Mitra ME, Melillo L, Aversa F, Van Lint MT, 27、50 Risk factors for invasive pulmonary fungal infection in patients with hematological malignancies not receiving hematopoietic stem cell transplant. Neoplasma. 2012;59(6):669-75. doi: 10.4149/neo_2012_085. Hu R, Jiang XY, Wu Y. 28、《中国过敏性哮喘诊治指南2019》 29、Diffusion tensor imaging and quantitative susceptibility mapping as diagnostic tools for motor neuron disorders. 30、Marginal mandibular versus pseudomarginal mandibular nerve injury with submandibular deoxycholic acid injection. Sorenson E, Chesnut C. Dermatol Surg 2018;44(05):733–735 31、1.J Clin Psychopharmacol. 2008 Apr;28(2):210-3. Long-acting injectable risperidone in the treatment of subjects with recent-onset psychosis: a preliminary study. 32、CNS Spectr. 2007 Oct;12(10 Suppl 17):21-6. Treatment adherence and long-term outcomes. 33、Continuous quality improvement in contract research organizations--the customer focus 34、Continuous quality improvement in contract research organizations--managing improvement processes 35、Regulatory Affairs - The Scientist - Magazine of the Life Sciences 36、International Pharmaceutical Product Registration 37、The Growth of the Cro Industry: Creating Value in Drug Development 38、From Laparoscopic Pyeloplasty to Robot-Assisted Laparoscopic Pyeloplasty in Primary and Reoperative Repairs for Ureteropelvic Junction Obstruction in Children 药典: 1、Calcium Folinate Injection2019 2、acetic acid,glacial BP2019 3、硫唑嘌呤片原料药BP标准 4、硫唑嘌呤片剂的BP标准 5、Calcium Folinate for InjectionBP2015 6、Rosuvastatin calcium 欧洲药典最新 EP10.1 7、2.4.10 Lead 铅 EP10 8、2.4.15 Nickel 镍EP10

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  • 2019-10-08

    1、Uberall MA, Lauffer H, Wenzel D. Parenteral substitution with intrave-¨ nous sodium valproate injection solution in children and adolescents with cerebral seizures. Nervenheilkunde 1998;17:278–282. 2、[5] Lundgren P. Stability and stabilization of carbachol in aqueous solution. Acta Pharm Suec 1969 Apr,6(2),299-312. 3、Lundgren P. Stability and stabilization of carbachol in aqueous solution. Acta Pharm Suec 1969 Apr,6(2),299-312. 4、Efficient Agrobacterium -mediated transformation and recovery of transgenic plants from pear( Pyrus communis L.)[J].Plant Cell Report.1996,16:215-219 5、Preliminary toxicokinetic study with different crystal forms of S (+)-ibuprofen (dexibuprofen) and R,S-ibuprofen in rats 6、Pharmacokinetics of dexibuprofen administered as 200 mg and 400 mg film-coated tablets in healthy volunteers.

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  • 2019-09-20

    1、Klin Anasthesiol Intensivther. 1993;44:3-10; discussion 108-13.[Pharmacodynamics and pharmacokinetics of the newer intravenous anesthetics (etomidate, propofol, S-ketamine)]. 2、Eur J Anaesthesiol. 1985 Jun;2(2):133-42. Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: etomidate as an example. Schüttler J, Schwilden H, Stoeckel H. 3、Responses of Total and Bioavailable 25-Hydroxyvitamin D and Factors Modifying the Responses: A Randomized, Placebo-Controlled Trial of Vitamin D3 Supplementation in an Asian Population 4、Preventative Approaches for Neuropathy in Diabetes with Alpha-lipoic Acid (PANDA Study) 5、Indacaterol/mometasone - Novartis Alternative Names: Mometasone furoate/indacaterol acetate; Mometasone/indacaterol; QMF-149 Latest Information Update: 13 Sep 2019

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  • 2019-09-06

    1.Evaluation of free-to-total prostate specific antigen (F/T PSA), prostate specific antigen density (PSAD) and (F/T)/PSAD sensitivity on reduction of unnecessary prostate biopsies for patients with PSA in gray zone. 2、Supermini NLP (SMP): Material, indicaciones, técnica, ventajas y resultados. 3、A new formulation of etomidate in lipid emulsion--bioavailability and venous provocation 4、Etomidate using a new solubilizer. Experimental clinical studies on venous tolerance and bioavailability 5、中国急性冠状动脉综合征防治现状蓝皮书2015

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  • 2019-08-29

    1、托伐普坦治疗ADPKD临床实践指南解读 2、Severino B, Luisi G, Donomae Iwamoto R, Moreno RA, Perez Teixeira V, Di Vaio P, Saccone I, Magli E, Santagada V, Caliendo G, Mendes GD, De Nucci G. 3、Executive summary on acetaminophen efficacy and safety. McNeil Consumer & SpecialtyPharmaceuticals. Data on file. 2002-9-19. Nonprescription Drugs Advisory Committee Meeting 2002 8 20 4、Polymorphism and pseudopolymorphism on nifedipine 5、Ullmann, vol.18, p.223 1979年的文献 6、Pharmacokinetics/dynamics following administration of a recombinant humanized monoclonal anti IgE antibody in the cynomolgus monkey

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  • 2019-08-20

    1、American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH, 2008, 2、内容:Totsuka K,Furukawa M,Furuya N,et al. PK/PD analysis of Tebipenem Pivoxil (ME1211),a Novel Oral Carbapenem Antibiotic,in otolaryngological infections,a phase II clinical trial (3).45th Intersci Conf Antimicrob Agents Chemother(ICAAC)(Dec 16-19. Washington,D.C.),2005,Abst L-579标题 PK/PD analysis of Tebipenem Pivoxil (ME1211),a Novel Oral Carbapenem Antibiotic,in otolaryngological infections,a phase II clinical trial; 3、PK–PD analysis of tebipenem pivoxil in clinical trials for pediatric patients. Jpn J Chemother. 2009;57(S-1):186–91. 4、Effect of meals and dosage-form modification on theophylline bioavailability from a 24-hour sustained-release delivery system. González MA1, Straughan AB. 5、Single dose study of the bioequivalence of two sustained-release theophylline formulations. Contreras J, Pérez N, González R, Ontivero E, López M. Arzneimittelforschung. 1998 Mar;48(3):259-62. 6、National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information., AD277-689 7、Graul, A.; Castaner, J.; Atorvastatin Calcium. Drugs Fut 1997, 22, 9, 956. 8、Formulation And Evaluation of Topical Aceclofenac Gel Using Different Gelling Agent(JAPAN PATEL1*, BRIJESH PATEL1, HARDEEPSINGH BANWAIT1, KAUSHAL PARMAR1,MANISH PATEL2 Department of Pharmaceutics, Sat Kaival College of Pharmacy, Sarsa, Anand, Gujarat, India Nootan Pharmacy College, Visnagar, Gujarat, India) 9、NCCN pediatric neuroblastoma practice guidelines. The National Comprehensive Cancer Network. Oncology (Williston Park). 1996 Dec;10(12):1813-22 10、Preliminary studies on toxic effects of some vulcanizing accelerators 11、Dose Dumping Dose dumping is an increased concern with drugs manufactured as modified-release (MR) formulations, that is, where drug release is controlled by a polymer matrix or a polymer coating.298298 From: FDA's Drug Review Process and the Package Label, 2018 12、Regulatory Considerations for Alcohol-Induced Dose Dumping of Oral Modified-Release Formulations Oct 02, 2015By Thomas P. Friebe, Firouz Asgarzadeh, Ann Gray, Kevin Hughes, Johann-Philipp Hebestreit, Yvonne Rosiaux, Mahmud Yunis, Amina Faham Pharmaceutical Technology Volume 38, Issue 10, pg 40-46 13、Novartis Pharmaceuticals. Lamisil (terbinafine hydrochloride) tablets [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp., 2005.

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  • 2019-08-05

    1、Effect of probenecid or diet on tebipenem pivoxil tablets pharmacokinetics in healthy male volunteers; 2、Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers; 3、Pharmacokinetics analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infection 1、Pharmacokinetic properties of isosorbide-5-mononitrate under fasting and fed conditions in healthy male subjects. Jin C, Jeon JY, Im YJ, Jeong JA, Kim Y, Chae SW, Bentz J, Kumke T, Kim MG. 7.The control of myopia with atropine.

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