34 累计需求单数
¥1,355,097.0 累计需求金额
0 违规次数

寻求一种模型,能够使用体外数据和仅有的的物化性质预测不同制剂在体内的性能。

悬赏
未托管赏金
¥15000.00
  1. 发布需求
  2. 药智客交稿
  3. 任务主选稿中
  4. 验收与付款
  1. 任务结束
任务结束
交易模式:
单人中标
赏金分配:
一人独享赏金,¥15000
具体要求:
目前,科学家们只能很有限的预测药物不同配方的生物利用度。尽管有广阔的临床前数据的药物,我们利用已知的分子性质和制剂在体内的数据并不能完全预测到药物的溶解性能,使得药品在体内部分的变化引起整个研究项目的变化。需求者对两种配方的10个不同的药物分子已经收集了大量在体外和体内的数据,现在寻求一种模型,能够使用体外数据和仅有的的物化性质预测不同制剂在体内的性能。具体如下:(https://www.innocentive.com/ar/challenge/9933559)
The Seeker is looking for ideas on how to use a variety of properties of molecules, and simple laboratory tests on different formulations to predict the change in a drug’s pharmacokinetic performance in biological systems resulting from different formulations. 

This is an Ideation Challenge with a guaranteed award for at least one submitted solution.


Source: InnoCentive      Challenge ID: 9933559
 
  Challenge Overview
Currently, scientists possess a limited ability to predict the bioavailability of different formulations of drugs despite vast pre-clinical data for the drugs. Utilizing measured properties of molecules and the dissolution performance of formulations to predict in vivo data is complex, and made more so by the inherent variability of in vivo data due partly to the variability of the test subjects. The Seeker has collected a significant amount of in vitro and in vivo data for two formulations each of 10 different molecules and would like Solvers to present ideas on how to use the in vitro data and simple molecular descriptors to predict the in vivo performance of different formulations. 

This is an Ideation Challenge, which has the following unique features:

There is a guaranteed award.  The awards will be paid to the best submission(s) as solely determined by the Seeker. The total payout will be $15,000, with at least one award being no smaller than $5,000 and no award being smaller than $1,000.  
Submission forwarding occurs during the Challenge.  Since submissions will be forwarded to the Seeker throughout the Challenge, please make sure you upload only a finished proposal. You can submit an updated version of your proposal only as a new submission. If you submit an updated version of your proposal, please clearly indicate the new items and/or edits compared to your previous submission. This will allow the Seeker to quickly find the new information and determine how it improves your submission.  
The Solvers are not required to transfer exclusive intellectual property rights to the Seeker.  Rather, by submitting a proposal, the Solvers grants to the Seeker a royalty-free, perpetual, and non-exclusive license to use any information included in this proposal. 


				
2014-12-23 13:16
0条新稿件,点击看看
还没有人交稿哦!
赶快点击交稿吧~

当前为付费需求,赏金分配方式:一人独享赏金。

任务主在众多备选稿件中选择最满意的稿件,支付赏金。

托管赏金,保障各方权益:

任务主把所发需求的悬赏金托管到药智网指定账户,以激发众多药智客的参与热情,保障任务主尽快征集到满意稿件;

同时,赏金托管也是为了保障参与挑战的药智客的正当权益。

流程说明:

发布需求

点击“发布需求”按钮,按照流程引导,将需求详情、具体要求描述清楚,发布到药智网的药智汇平台。

托管赏金

为征集到满意稿件,任务主须做好“赏金预算”,并将赏金托管到药智网指定账户,打消药智客的顾虑,激励药智客积极参与需求挑战。

药智客参与

任务主托管赏金后,所发布的需求显示“赏金已托管”字样。只有托管了悬赏金的需求,能够鼓舞众多的药智客参与,获取到满意的稿件!

选择满意稿件

任务主在众多参与者提交的稿件中,选择符合任务主需求的稿件。再通过互动,选择任务主最满意的稿件,并确定其为中标稿件。

验收与付款

中标稿件提交任务主验收。任务主在验收/验证期内,完成验收/验证工作。对合格稿件,通知药智网支付佣金。

评价

双方可以针对本次交易各自的表现进行评价,评价结果将影响各自的信用度和能力值。

类似的需求

    加载数据中...

该需求者还有这些需求

    加载数据中...

推荐需求

    加载数据中...
感兴趣,就投稿吧!投的越早,中标几率就越大! 收藏
扫一扫,关注药智汇微信
及时获得最新药智汇信息

2014 药智再发力 我们换装了!!

为了让您有更好的体验,药智对用户体系和产品进行了全新升级!

我要看看