34 累计需求单数
¥1,355,097.0 累计需求金额
0 违规次数

阿斯利康公司2015年的新需求

悬赏
未托管赏金
¥25000.00
  1. 发布需求
  2. 药智客交稿
  3. 任务主选稿中
  4. 验收与付款
  1. 任务结束
任务结束
交易模式:
单人中标
赏金分配:
一人独享赏金,¥25000
具体要求:
药物代谢酶的过程中,肝脏是主要负责将药物基质脂溶性化合物转化为水溶性代谢物,可以很容易地通过肾脏排泄的。偶尔,这些代谢产物也会不恰当地和血蛋白结合,从而导致药物的不良反应。阿斯利康希望寻找一种定量测定共价结合细胞蛋白质的新方法。具体的链接请看下面:
https://www.innocentive.com/ar/challenge/9933662
AWARD: $25,000 USD  |  DEADLINE: 3/16/15  |  ACTIVE SOLVERS: 74  |  POSTED: 1/16/15 

Drug metabolism is the enzymatic process by which the body modifies pharmaceutical substrates. The liver is primarily responsible for reactions which convert lipid-soluble compounds into water-soluble metabolites that can easily be excreted by the kidney. Occasionally, these metabolites exhibit chemically reactivity towards host proteins, leading to inappropriate binding that may result in adverse drug reactions. AstraZeneca desires an innovative approach for the quantitative measurement of covalent binding to cellular proteins.

This Challenge requires only a written proposal.


Source: InnoCentive      Challenge ID: 9933662
 
  Challenge Overview
When new medicines are introduced to the market, not only does the drug need to have a proven therapeutic benefit, but it also must possess an acceptable safety profile. To this end, drug development focuses on minimizing adverse drug reactions (ADRs) and idiosyncratic drug toxicities. ADRs are a major complication of drug therapy and come as a result of drug accumulation and/or the formation of chemically reactive metabolites (CRMs). Formation of CRMs within a cell poses an undesirable chemical liability and for this reason, AstraZeneca desires an innovative approach for the quantitative measurement of covalent binding of metabolites to cellular proteins.

ABOUT THE SEEKER

AstraZeneca is a global, research-based, biopharmaceutical company with a focus on five key therapeutic areas: 1) cardiovascular & metabolic diseases, 2) oncology, 3) respiratory, inflammation & autoimmunity, 4) neuroscience, and 5) infection. As an innovation-driven, research organization, AstraZeneca recognizes that great ideas come from many sources. Open innovation is an avenue by which ideas can be shared and AstraZeneca recently launched a pavilion to further its commitment to facilitate the advancement of pharmaceutical research.


				
2015-01-24 14:08
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