13 累计需求单数
¥3,000.0 累计需求金额
0 违规次数

描述出可能会成为制药巨大改变的事件

悬赏
未托管赏金
¥0.00
  1. 发布需求
  2. 药智客交稿
  3. 任务主选稿中
  4. 验收与付款
  1. 任务结束
任务结束
交易模式:
单人中标
赏金分配:
一人独享赏金,¥0
具体要求:
“科技每年都会见证一些神奇的真理和制造出令人眼花缭乱的东西,如吴雨霏穆利斯《创新的聚合酶链式反应》。 不幸的是,他们中的大多数被淘汰出局。而聚合酶链式反应则预示着基因组的革命. 这是一项关于思维的挑战,这项任务要求挑战者来概述制药行业需要采取哪些创新,来适应这优胜劣汰的游戏规则。挑战者不需要发表明确的解决方案,你只需要清楚的描述已经存在的,可能会成为下一个制药趋势的大事。这将有助于制药行业寻找明天的药物,生产新药。 What Disruptive Innovations Does Pharma Need To Discover Tomorrow’s Drugs? AWARD: $5,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 220 | POSTED: 9/14/12 Source: InnoCentive Challenge ID: 9932826 Type: Ideation Detailed Description & Requirements Background Productivity in drug discovery & development – the number of new drugs reaching patients – has been declining. At the same time, R&D spending has been increasing. Industry experts calculate the mean R&D spend per new drug on the market is $4-11 billion dollars. 2012 Forbes Article: The Truly Staggering Cost of Inventing New Drugs The Problem Various factors contribute to this high development cost. The most prominent is the high rate of attrition (failure) on drug like compounds as they pass through the drug development process. For every 10,000 compounds that appear interesting during basic research, 1 may reach market as an approved drug. Causes of compounds not progressing include: Lack of efficacy or potency Unfavorable pharmacology/pharmacodynamics Toxicity or safety Increasing regulatory stringency in approving drugs for clinical trial and for market Increasing emphasis on stratification of patient populations for administration of drugs (personalized medicine) Factors contributing to these causes include, but are not limited to: Assay systems and platforms that poorly replicate drug effects in humans Lack of new therapeutic drug targets being identified e.g. phenotypic screening data is difficult to convert into new molecular targets Animal experimental data, too, poorly predicts effects in humans / translational medicine Lack of good validated biomarkers to measure disease states or predict responses to drugs The Solution The Seeker requires your well thought out ideas and game changing approaches to help pharma address one of the following questions. Choose one of the following for your submission, describe your game changing solution & justify how it will address any one or more of the problem causes and factors listed above. Choose one of the following: What are the new game changers affecting how we find new drugs e.g. new in-silico modeling approaches, new biological sources or screens? What will be the next big technology that enables better drug candidates, molecular targets or biomarkers to be identified i.e. game changing technologies in molecular biology, synthetic chemistry, cell-based models? How could clinical trials be better designed and implemented i.e. faster, more cost effective or producing better data? How could best value be delivered top patients The Seeker is not interested in published approaches, suggestions of individual drug candidates, or specific assays – proposals describing novel, creative & GAME CHANGING innovations are required. You don’t need to invent the solution; you just need to clearly describe what is already out there that has the potential to become ‘the next big thing’ that will help make the Pharma industry more productive finding the drugs of tomorrow. Project Criteria Submitted proposals along with all relevant supporting data should include the information described in the Detailed Description of the Challenge. Your proposal should include: A detailed description of features of ‘the next big thing’, including Insights into how it addresses one or more of the causes and factors of the problem as outlined above An outline of what ‘the next big thing’ would enable for the pharma industry Any supporting evidence, such as reference to the literature (patent, commercial or academic). Submitted proposals should not include any personal identifying information the Solvers do not want to make public, or any information the Solvers may consider as their Intellectual Property they do not want to share. This is an Ideation Challenge, which has the following unique features: There is a guaranteed award. The awards will be paid to the best submission(s) as solely determined by the Seeker. The total payout will be $5,000, with at least one award being no smaller than $3,000 and no award being smaller than $1,000. The Solvers are not required to transfer exclusive intellectual property rights to the Seeker. Rather, by submitting a proposal, the Solvers grants to the Seeker a royalty-free, perpetual, and non-exclusive license to use any information included in this proposal. After the Challenge deadline, the Seeker will complete the review process and make a decision with regards to the Winning Solution(s).All Solvers that submitted a proposal will be notified on the status of their submissions; however, no detailed evaluation of individual submissions will be provided.
2012-09-27 11:52
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