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Disulfiram 我想要一份USP版本的分析单   [更多]

寻找一个有经验的会不锈钢金属蚀刻技术的合作伙伴。要求该合作伙伴精通蚀刻工艺的精度控制，并且具备大规模的生产能力，能在未来起到重要作用。 这是一项寻找合作伙伴的任务，要求提交一份关于建立合作伙伴关系的书面建议书。 Precise Chemical Metal Etching AWARD: varies | DEADLINE: 11/09/12 | ACTIVE SOLVERS: 6 | POSTED: 9/25/12 Source: InnoCentive Challenge ID: 9933182 Type: eRFP Detailed Description & Requirements Background The Seeker has a product whose parts are made by the precise chemical etching of thin Stainless Steel sheets. Stainless steel etching is not very common for precision parts because the requirements are usually too strict for the etching techniques due to underetching. The Seeker has pushed the limits of the metal etching process and has developed processes that potentially work for their application. The Seeker is now looking for partners who can do precision SS etching to potentially become suppliers of parts that will number in the hundreds of millions per year in total. The partner will have developed their own specialized etching technique to make the structures required. The Challenge and Opportunity We are seeking companies which are specialized in chemical metal etching of stainless sheet steel (~200 – 300 ?m thickness). The desired partner should be able to produce the structures on the template below using an etching technique. (Note: For easier viewing, a larger copy of the drawing is attached to this Challenge.) We do not expect the Solvers to actually produce the template structures for this Challenge, but show that they have the skills and equipment to potentially produce the structures. If selected as a potential partner by the Seeker after the Challenge, then you will be asked to produce the structures directly for the Seeker. The template is not the actual part of interest, but the Seeker is confident if you can reproduce the template, then it will translate to making the part. Figure 1- Etching Structure Template It should absolutely be clear that when using an etching technique, the   [更多]

这是一项关于寻找材料加工技术的任务，要求是要用纳米团簇生产含能材料，这个技术的重点要是在一个可控的过程中进行，要有稳定的空气和粒子率增加一致。 这个任务需要提交一份书面的建议书 Energetic Core-Shell Nanocluster Production AWARD: $20,000 USD | DEADLINE: 11/19/12 | ACTIVE SOLVERS: 116 | POSTED: 9/19/12 Source: InnoCentive Challenge ID: 9932739 Type: Theoretical-licensing Detailed Description & Requirements Background Core-shell nanoclusters are groups of atoms of usually 2 materials in an arrangement such that one material, in the center, is the “core” of atoms which is coated with atoms of another material or the “shell”. These clusters contain from 10’s to millions of atoms and aggregates are in the nanometer range (~5 to 1000 nm). An example would be a core of Fe atoms and a shell of Au atoms. The Fe would not be stable as it would oxidize quite rapidly on its own, but the gold shell protects it from oxidation, yet the small clusters still exhibit magnetic behavior. This is the most simplistic core-shell and there are many different arrangements with multiple materials and multiple shells and the Solvers can look at the references attached for more information. Nanoclusters are unique as they exhibit properties different from bulk materials which are many times cluster size dependent. Of particular interest are highly energetic materials such as mixtures of metals and metal oxides. As nanoclusters, these materials have increased reactivity, because mass transport is removed as a barrier between fuel and oxidizer (i.e. all atoms are in intimate contact). Using the classic thermite reaction, an Al core of atoms could be coated with Fe Oxide which would protect the Al from oxidation. When ignited as nanoclusters the reaction rate would be increased over the bulk materials. The Challenge The Seeker is interested in material processing technologies for the production or fabrication of nano-scale core-shell cluster energetic materials with particle diameters between 5 and 25 nm. This process has been done in   [更多]

任务材料需要提供与化合物相匹配的核心结构和每种化合物合成的详细的参考依据。合格者会得到一定的奖励。将给予每种化合物知识产权转让费9000元，非独家许可使用化合物，以达到研究目的，比如：研究化合物分子的性质和分子衍生物。 Seeking Bicyclic Aminoketones AWARD: varies | DEADLINE: 10/22/12 | ACTIVE SOLVERS: 24 | POSTED: 9/21/12 Source: InnoCentive Challenge ID: 9932910 Type: RTP Detailed Description & Requirements Intellectual Property: In return for the Initial Transfer Fee of $1,500 per compound, you are expected to grant the Seeker only a non-exclusive license to use your compound for internal, research purposes (for example, researching the molecule’s properties or preparing derivatives of the molecule). Material supply of non-commercial compounds matching the shown core structures is desired. For Solvers’ information, procedures for preparing compounds of this type may be found in the following references: Synthesis, 1, 1979, 50. Synthesis, 3, 2010, 493. Tetrahedron, 68 (4), 2012, 1286. J. Organic Chem, 73 (6), 2008, 2114. J. Med. Chem, 37 (18), 1994, 2831. More specifically, the Seeker is looking for compounds that meet the following Requirements: Structure: FeatureRange StructureA bicyclic aminoketone as shown in the structures above. Elements in R and A groupsR = H, Me, or protecting group (preferably Boc) A = A 1-3 membered linker where one atom may be N, O, or S Substituents– In addition to H, the core rings and/or the A linker may be substituted with Me or F. Unsaturation– The core rings and/or the A linker may include an olefin, including an exo olefin, but may not contain any additional carbonyl groups. Additional Rings– The Seeker would prefer compounds that have only the bicyclic structure shown above, however, they may consider compounds with an additional ring fused to the core bicycle. Stereochemistry– The Seeker will only consider compounds which are single diastereomers. In cases where the compound may exist as two enantiomers, the Seeker will consider   [更多]

这项任务要要求设计一个自动化的，高通量的仪器 ， 可以定量地和可重复地测定的油水乳化液的分离。 这个任务需要提交一份书面建议书。 An Instrument for Quantitative, Reproducible Characterization of Water/Oil Emulsions AWARD: $30,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 508 | POSTED: 8/15/12 Source: InnoCentive Challenge ID: 9933086 Type: Theoretical-IP Transfer Detailed Description & Requirements The presence of emulsions in oil operations is common and generally undesirable. Crude oil emulsions typically form due to the presence of naturally occurring emulsifying agents (asphaltenes, resins, etc.) in crude oil. The high cost associated with transportation and corrosion of equipment is one of the problems caused by the presence of water in the crude oil. Therefore, oil dehydration is required, which is often achieved through chemical treatment using demulsifiers. While the Seeker has identified ~200 liquid “demulsifier” agents, compounds that in amounts of ~100-500 ppm can aid in the resolution of the water and oil phases, they lack a quantitative and reproducible assay for determining demulsifier effectiveness at resolving the emulsion. Currently, the Seeker performs a “bottle test” in which they add ~15-100 mL of the emulsion into a bottle, add the different demulsifiers, shake, and then visually observe which bottles show the best phase separation. This assay clearly relies on visual detection by a trained observer and is not nearly as quantitative or reproducible as the Seeker desires. Results from a bottle test with the same emulsion and three different demulsifiers are shown below. The bottle on the left has clearly not been resolved into two distinct phases. While the middle bottle shows significant improvement, careful inspection of the phase boundary shows a slight amount of oil contaminating the water layer and a slightly undefined interface. Finally, the bottle on the right shows an optimally resolved two-phase system with a very clear oil/water phase boundary. Important Note:   [更多]

“科技每年都会见证一些神奇的真理和制造出令人眼花缭乱的东西,如吴雨霏穆利斯《创新的聚合酶链式反应》。 不幸的是，他们中的大多数被淘汰出局。而聚合酶链式反应则预示着基因组的革命. 这是一项关于思维的挑战，这项任务要求挑战者来概述制药行业需要采取哪些创新，来适应这优胜劣汰的游戏规则。挑战者不需要发表明确的解决方案，你只需要清楚的描述已经存在的，可能会成为下一个制药趋势的大事。这将有助于制药行业寻找明天的药物，生产新药。 What Disruptive Innovations Does Pharma Need To Discover Tomorrow’s Drugs? AWARD: $5,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 220 | POSTED: 9/14/12 Source: InnoCentive Challenge ID: 9932826 Type: Ideation Detailed Description & Requirements Background Productivity in drug discovery & development – the number of new drugs reaching patients – has been declining. At the same time, R&D spending has been increasing. Industry experts calculate the mean R&D spend per new drug on the market is $4-11 billion dollars. 2012 Forbes Article: The Truly Staggering Cost of Inventing New Drugs The Problem Various factors contribute to this high development cost. The most prominent is the high rate of attrition (failure) on drug like compounds as they pass through the drug development process. For every 10,000 compounds that appear interesting during basic research, 1 may reach market as an approved drug. Causes of compounds not progressing include: Lack of efficacy or potency Unfavorable pharmacology/pharmacodynamics Toxicity or safety Increasing regulatory stringency in approving drugs for clinical trial and for market Increasing emphasis on stratification of patient populations for administration of drugs (personalized medicine) Factors contributing to these causes include, but are not limited to: Assay systems and platforms that poorly replicate drug effects in humans Lack of new therapeutic drug targets being identified e.g. phenotypic screening data is difficult to convert into new molecular targets Animal experimental data, too, poorly predicts effects in humans / translational medicine Lack of good validated biomarkers to measure disease states or predict   [更多]

实验室拟邀请4位研究人员进行他们的研究项目。研究地点是在位于西班牙的葛兰素史克公司的药物开发园。研究人员的生活费，旅游资金，住宿费和研究所花的耗材成本皆由实验室承担。4个研究项目，每一个都有16万美元的预算。任务要求：需要有疟疾病，肺结核病和动质体疾病(南美锥虫病，利什曼病，昏睡病)等领域的开放性的研究。这项挑战的优胜者请直接联系实验室，以便根据他们的反馈和指导，做出更全面的考虑。这是一项寻找合作伙伴的任务，要求提交一份书面企划书以做评估。 Tres Cantos Open Lab Foundation: Proposals for Neglected Diseases Research TAGS: Developing Countries, Requests for Partners and Suppliers, Life Sciences, Food/Agriculture, Nature, Global Health, Computer Science/Information Technology, Chemistry, Physical Sciences, Public Good, eRFP AWARD: varies | DEADLINE: 10/29/12 | ACTIVE SOLVERS: 92 | POSTED: 9/17/12 The Tres Cantos Open Lab Foundation intends to invite up to 4 Solvers to conduct their research projects using the facilities and resources of GlaxoSmithKline’s Tres Cantos Medicines Development Campus in Spain. Researcher subsistence, travel, accommodation & consumable costs can be covered by the Tres Cantos Open Lab Foundation. Four research projects are budgeted for, each having a maximum funding of $160,000. Proposals for groundbreaking research in the areas of malarial disease, tuberculosis and kinetoplastid diseases (Chagas Disease, Leishmaniasis or Sleeping Sickness) are required. The winners of this challenge will be contacted directly by the Tres Cantos Open Lab Foundation in order to make more comprehensive proposals based on their feedback and guidance. This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit a written proposal to be evaluated by the Seeker with a goal of establishing a collaborative partnership. Source: InnoCentive Challenge ID: 9933167 Challenge Overview Are you a researcher who would like to spend from 6 to 24 months at the world class facilities of the open lab at GSK’s Tres Cantos Medicines Development Campus in Spain carrying out research that will positively impact the lives of people in the developing world? Funding for up to 4 research projects totaling up to $160,000   [更多]

RT，要求上述所罗列项目包括了菌种、发酵工艺、后提取精制工艺及相应的参数指标。   [更多]

需求描述： 口腔硬组织很容易聚集牙垢和牙菌斑。需要确定经证明能防沉积并轻松去除沉积物的技术和产品。 我们寻求： 比传统口腔护理产品(牙膏和漱口水)防附着性能更强的产品 ¨ 益处能持续一段时间(距离下一次刷牙)且比目前市场上的口腔护理产品更优越 ¨ 技术/产品必须与钠和氟化亚锡相容 ¨ 防附着机制必须不影响牙釉质吸收氟 所关注的益处 预防牙菌斑 预防牙垢 预防牙结石 ¨ 产品形式可包括 牙膏(液态) 漱口水(液态) 凝胶(非液态) ¨ 最好是具有下列特征的技术： 从软硬组织沉积、留存并释放物质的技术 所有基于液态的口腔护理制剂均有性能、稳定性和相容性相关数据 有相当于适当阴性对照组的性能数据(技术/消费者/临床) 有能证明和量化益处的独特能力 人体安全性已得到确认或材料得到美国公认安全认证(GRAS) 使用产品后有明显清洁感 获得专利保护 我们对下列技术不感兴趣： 不受强有力知识产权保护的技术 需要广泛的安全许可或监管部门批准的技术 稿件提交网址：宝洁联系与发展部http://www.pgconnectdevelop.cn   [更多]

“洗衣粉漂洗泡沫控制技术” 对象 我们希望合作伙伴能够提供外源专业技术，以找到一种能够有效及高效地抑制洗衣粉漂洗泡沫而同时又不会影响洗涤泡沫及(或)清洗效果的新技术。 背景 在洗衣过程中，消费者非常重视洗衣粉的泡沫量，特别是手洗时。 我们希望有一种技术能够有选择性地抑制漂洗阶段的泡沫量，而同时不影响洗涤阶段的泡沫量。 要实现此目标所面临的挑战涉及两个看起来相互矛盾的流程：添加剂必须能够在漂洗阶段有效地抑制泡沫量。 然而，该添加剂在洗涤阶段必须保持非活性状态，不得影响洗涤中的泡沫量。 目标 我们需要的是： A. 能够有选择性地在首次漂洗过程中抑制 90% 的泡沫量。 B. 对洗涤中的泡沫量影响较少或无影响，洗涤泡沫量与添加前相比，至少保持原泡沫量的 80%. 成功标准 评判解决方案是否成功的关键准则包括： · 在首次漂洗过程中能够抑制 90% 以上的泡沫量。 · 洗涤过程中对泡沫的抑制量不超过 20%。 · 不会对清洗效果和织物净白产生不良影响 · 满足人身和环保安全法规 · 不会显著地影响产品的稳定性，时间长时不会出现变色或变味。 · 具有让产品占据专有地位及推进产品优势声明的可能。 · 价格可行。 其性能将在洗衣粉中进行评估。 其他重要信息 Ø 需要提供相应的样品，以由宝洁公司进行初始检测。初始样品的数量应为 0.2-5 千克。 有关回应的其他评估标准 宝洁公司将采用如下标准对各响应进行评估： · 所提议方法的整体科学和技术优点 · 用于保证实现其设计概念或性能的方法 · 实现专有地位的可能(即技术的创新性或可申请专利性) · 所提议概念的经济潜力 · 提供方的实力及相关经验 · 规模生产和商业化所需的时间 保密 提交回应，表明您认同了所提交的回应中不包含任何类型的保密性信息。 如果需要，可提供一份 CDA 以便能够更加详细的讨论或是交流信息。 稿件提交网址：宝洁联系与发展网http://www.pgconnectdevelop.cn   [更多]