标题： 1、Prostanoids for chronic critical leg ischemia. A randomized, controlled, open-label trial with prostaglandin E1. The ICAI Study Group. Ischemia Cronica degli Arti Inferiori. 2、Removal ofcysteinylation from an unpaired sulfhydryl in the variable regionof a recombinant monoclonal IgG1 antibody improves homogeneity，stability，and biological activity 3、Pharmacokinetics of fixed-dose combination of tenofovir disoproxil fumarate, lamivudine, and efavirenz: results of a randomized, crossover, bioequivalence study。 4、Synthesis and biological evaluation of bis(methoxymethyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolines as EGFR tyrosine kinase inhibitors. Lee, Yong Sup; Seo, Seon Hee;Yang, Beom-Seok; Lee, Jae Yeol Archiv der Pharmazie (Weinheim,Germany) Volume 338 Issue 10 Pages 502-505 Journal 2005 5、Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: Synthesis of 18FIressa and related molecular probes. Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S. Journal of Labelled Compounds & Radiopharmaceuticals Volume 48 Issue 11 Pages 829-843 Journal 2005 6、 Kinetic study of a 2-hydroxypropyl - -cyclodextrin-based formulation of all -trans-retinoic acid in Sprague-Dawley rats after oral or intravenous administration. Lin HS,Chan SY,Low KS,et al. Journal of Pharmacological Sciences . 2000 7、 Design and in vivo testing of 17-beta estradial -HP beta CD sublingual tablets. Fridriksdottir H,Loftsson T,Gudmundsson JA,et al. Pharmazie . 1996 8、 Hydroxypropyl - -cyclodextrin derivatives: influence of average degree of substitution on complexing ability and surface activity. Muller BW,Brauns U. Journal of Pharmacological Sciences . 1986 9、 Cyclodextrins as co-enhancers in dermal and transdermal drug delivery. Loftsson T,Masson M,Sigurdsson HH,et al. Pharmazie . 1998 10、 Effect of 2hydroxypropyl - -cyclodextrin on percutaneous absorption of methyl paraben. Tanaka M,Iwate Y,Kouzuki Y,et al. Journal of Pharmacokinetics and Pharmacodynamics . 1995 要求：将符合的文献PDF文档打包上传

标题： 1、Perindopril-based blood pressure lowering reduces major vascular events in Asian and Western participants with cerebrovascular disease: the PROGRESS trial 2、Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice: results from the STRONG prospective, observational, multicenter study 3、Bioequivalence study of two perindopril erbumine tablet formulations in healthy volunteers 4、Development and in vitro/in vivo evaluation of immediate release perindopril tablets 5、The advantages of combination therapy on hypertension: development of immediate release perindoprilindapamide tablet and assessment of bioequivalence studies 6、Does Chinese ethnicity affect the pharmacokinetics and pharmacodynamics of angiotensin-converting enzyme inhibitors? - PubMed - NCBI 7、Drug Dev Ind Pharm. 2013 Jul;39(7):996-1004. doi: 10.3109/03639045.2012.689765. Epub 2012 May 25. A potent preparation method combining neutralization with microfluidization for rebamipide nanosuspensions and its in vivo evaluation. Shi Y1, Zou M, An Y, Ji Z, Gao P, Cheng G. 8、Drug Dev Ind Pharm. 2006 Jul;32(6):651-60. Production of an extremly low dose procaterol HCl preparation by fluidized-bed coating method: in vitro and in vivo evaluation. Yu TW1, Chen RR, Gau CS. 9、Enhancement of solubility and dissolution of cilostazol by solid dispersion technique. Park JH, Choi HK. Arch Pharm Res. 2015 Jul;38(7):1336-44. doi: 10.1007/s12272-014-0547-6. Epub 2015 Jan 8. 10、Solid-state amorphization of rebamipide and investigation on solubility and stability of the amorphous form. Xiong X, Xu K, Li S, Tang P, Xiao Y, Li H. Drug Dev Ind Pharm. 2017 Feb;43(2):283-292. doi: 10.1080/03639045.2016.1239627. Epub 2016 Oct 6. 要求：将符合要求的文献PDF格式打包上传

标题： 1、Morisset M et al. Allergy to cow milk proteins contaminating lactose, common excipient of dry powder inhalers for asthma. J Allergy Clin Immunol 2006; 117(Suppl. 1): 95 2、Safety and tolerability of selumetinib as a monotherapy, or in combination with docetaxel as second-line therapy, in Japanese patients with advanced solid malignancies or non-small cell lung cancer. 3、Preparation and characterization of a cocrystalline suspension of [LysB28,ProB29]-human insulin analogue. DeFelippis MR1, Bakaysa DL, Bell MA, Heady MA, Li S, Pye S, Youngman KM, Radziuk J, Frank BH 1、Heterocycles, 2001 , vol. 55, # 2 p. 331 - 352 4、R. G. Strickley, L. Liu, and P. Lapresca. Preclinical parenteral and oral formulations of water insoluble molecules. ISSX Meet- ing, Nashville, TN (USA) Abstract # 291 (1999). (Z) 5、465: A possible genetic signature of DNA repair genes in triple negative breast cancers by a NGS approach 4、Systemic exposure to?atorvastatin?between Asian and Caucasian subjects: a combined analysis of 22 studies. 6、 Evaluation of cardiovascular morbidity associated with adherence to?atorvastatin?therapy. 7、Beta-lactam antibiotics: their role in the management of infections in children 8、China type 2 diabetes treatment status survey of treatment pattern of oral drugs users. J Diabetes. 2015 Mar;7(2):166-73 9、Non‐steroidal anti‐inflammatory drugs and upper gastrointestinal bleeding, a post‐marketing surveillance case‐control study 10、Individual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. 备注：将符合要求文献的PDF格式打包上传

文献标题： 1.The pathobiology of diabetic complications: a unifying mechanism. 2.Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products. 3.A Berberine-Loaded Electrospun Poly-(ε-caprolactone) Nanofibrous Membrane with Hemostatic Potential and Antimicrobial Property for Wound Dressing. 4.China type 2 diabetes treatment status survey of treatment pattern of oral drugs users. J Diabetes. 2015 Mar;7(2):166-73 5.Non‐steroidal anti‐inflammatory drugs and upper gastrointestinal bleeding, a post‐marketing surveillance case‐control study 6.Individual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. 备注：将符合要求的文献的PDF格式打包上传

要求: 1.The pathobiology of diabetic complications: a unifying mechanism. 2. 文章：Amoxicillin/clavulanic acid (875/125): Bioequivalence of a novel Solutab tablet and rationale for a twice-daily dosing regimen 作者：Sourgens, H. 期刊：International journal of clinical pharmacology and therapeutics ISSN：0946-1965 日期：2004 卷：42 發行號：3 頁面：165 - 173 3.文章：Bioequivalence study of a novel Solutab tablet formulation of amoxicillin/clavulanic acid versus the originator film-coated tablet 作者：Sourgens, H. 期刊：International journal of clinical pharmacology and therapeutics ISSN：0946-1965 日期：2001 卷：39 發行號：2 頁面：75 - 82 4.Pharmacokinetic comparison of amlodipine adipate/ valsartan fixed-dose combination with amlodipine besylate/ valsartan fixed-dose combination in healthy volunteer 5.Characteristics of the PIVKA-II found in hepatocellular carcinoma, investigation using monoclonal antibodies MU-3 and 19B7 6.The des-γ-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma 将符合要求的文献的PDF格式打包上传

文献标题: 1. Dutasteride in Androgenetic Alopecia: An Update 2. Identification of 5α-reductase isoenzymes in canine skin 3. 5α-reductases in human physiology: an unfolding story 4. Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride 5.Real-world clinical experience of amlodipine/ valsartan and amlodipine/ valsartan/hydrochlorothiazide in hypertension: the EXCITE study 6.Real-world effectiveness of amlodipine/alsartan and amlodipine/alsartan/hydrochlorothiazide in high-risk patients and other subgroups 要求: 将上述标题文献PDF格式打包上传

文献标题: 1.Micronization of Active Pharmaceutical Ingredients (API) – from R&D to the production scale 作者：S Mende 2. Crit Care Med. 2011 Feb;39(2):259-65. doi: 10.1097/CCM.0b013e3181feeb15. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Boyd JH1, Forbes J, Nakada TA, Walley KR, Russell JA. 3. Crit Care Med. 2006 Feb;34(2):344-53. Sepsis in European intensive care units: results of the SOAP study. Vincent JL1, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D; Sepsis Occurrence in Acutely Ill Patients Investigators. 4.Pharmacokinetic comparison and bioequivalence evaluation of?losartan/ hydrochlorothiazide tablet between Asian Indian and Japanese volunteers. Kumar S,?Monif T,?Khuroo A,?Reyar S,?Jain R,?Singla AK,?Kurachi K. 5.Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics 6.Dev Sci. 2014 Nov;17(6):977-83. doi: 10.1111/desc.12171. Epub 2014 Mar 17. Follow the liar: the effects of adult lies on children's honesty. Hays C1, Carver LJ. 7.Investigation of bioequivalence of a new fixed-dose combination of acarbose and metformin with the corresponding loose combination as well as the drug-drug interaction potential between both drugs in healthy adult male subjects. 要求: 打包上传符合要求的文献的PDF格式

文献标题: 1.Development and evaluation of chitosan based oral controlled matrix tablets of?losartan?potassium J Pharm Investig.?2012 Jul;2(3):157-61. doi: 10.4103/2230-973X.104399. 2.Response criteria of tolvaptan for the treatment of hepatic edema J Gastroenterol. 2017 Jun 29. 3.Hepatol Res.?2017 Oct 6. doi: 10.1111/hepr.12988. [Epub ahead of print] Increased?serum?C-reactive?protein?and?decreased?urinary?aquaporin?2?levels?are?predictive?of the?efficacy?of?tolvaptan?in?patients?with?liver?cirrhosis. 4.Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range. 5.An evaluation of fit factors and dissolution efficiency for the comparison of in vitro dissolution profiles 6.Anatol J Cardiol.?2017 Sep;18(3):213-214. doi: 10.14744/AnatolJCardiol.2017.8033. Tolvaptan?in the very elderly with acute decompensated heart failure- a therapeutic option worth of consideration. 7.紫外-可见分光光度法测定依达拉奉注射液中的亚硫酸氢钠含量 8.Anatol J Cardiol. 2017 Sep;18(3):213-214. doi: 10.14744/AnatolJCardiol.2017.8033. Tolvaptan in the very elderly with acute decompensated heart failure- a therapeutic option worth of consideration. 备注: 将符合要求的文献PDF格式打包上传

文献名称: 1.A Systematic Review and Meta-analysis of Efficacy and Safety of Novel Interleukin Inhibitors in the Management of Psoriatic Arthritis. J Clin Rheumatol. 2017 Sep 19. 2.A review article on brodalumab in the treatment of moderate-to-severe plaque psoriasis.Immunotherapy. 2017 Sep;9(12):963-978 备注 : 将符合要求的文献PDF格式上传

文献名称: 1.Sodium Diisopropylamide in Tetrahydrofuran: Selectivities, Rates, and Mechanisms of Arene Metalations 2.Advances toward LSD1 inhibitors for cancer therapy　 3.Serum HER2 extracellular domain levels and HER2 circulating tumor cell status in patients with metastatic breast cancer 4.Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder. 5.The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. 6. G.A. Digenis, The in vivo behavior of multiparticulate versus single unit dose formulations, CAPSUGEL’s Symposium in Seoul, 1990. 7.Stability of salicylic acid and magnesium stearate by DSC 作者：L Macpherson ， S Sauerbrunn 出版源：《American Laboratory》 , 2006 , 38 (14) :16-20 备注 : 将符合要求的文献PDF格式上传