PXE – Evaluating Hypotheses and Suggesting Experiments for a Rare Disease
TAGS: Computer Science/Information Technology, Chemistry, Global Health, Nature, Public Good, Life Sciences, Ideation
AWARD: $7,000 USD | DEADLINE: 11/30/12 | ACTIVE SOLVERS: 38 | POSTED: 10/31/12
The Seeker, PXE International, the primary group responsible for funding PXE research, presents two existing hypotheses (an active circulating metabolite(s) or a tissue-specific dysfunction) for the rare disease Pseudoxanthoma Elasticum (PXE). The Seeker requests that Solvers present evidence favoring one of the two hypotheses, then provide additional experiments to conduct to further knowledge around the disease mechanism.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution. In addition to the Challenge award, PXE International will also assist finalists in efforts to obtain funding for PXE-related research.
Detailed Description & Requirements
INTRODUCTION TO PXE
Pseudoxanthoma Elasticum (PXE) is a recessive genetic disorder with signs and symptoms that mimic many aspects of the normal aging process, but at a much younger age (when people are roughly between 10 and 20 years old). Specifically, the disease is characterized by fragmentation and mineralization of elastic fibers in certain tissues. Some of the more common symptoms, in general order that they occur, are:
Wet-type macular degeneration
Calcification of blood vessels
PXE is a rare disease with an estimated patient population of 12,000 people. Given the small number of people with the disease, it has not been the subject of research by for-profit pharmaceutical and biotech companies. [更多]