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重性抑郁障碍（MDD）是一种使人衰弱的精神障碍，在美国约有20000000流行病例。然而不同的抗抑郁药可用于治疗不同的抑郁症，，约50%的抑郁症患者的初始治疗结果不理想。最近有证据表明，在发病的几个小时内氯胺酮给药治疗难治性抑郁症已经显著有所改善。勃林格殷格翰公司寻找氯胺酮在人体中反应和持续的抗抑郁作用的机理。 Boehringer Ingelheim Challenge: Understanding the Antidepressant Effect of Ketamine TAGS: Nature, Chemistry, Life Sciences, Ideation AWARD: $21,000 USD | DEADLINE: 1/15/15 | ACTIVE SOLVERS: 20 | POSTED: 12/15/14 1. The Challenge and qualification for the award Major depressive disorder (MDD) is a debilitating psychiatric disorder with about 20 million prevalent cases in the United States. Various antidepressants are available for treatment of patients suffering from MDD, however, about 50% of MDD patients do not respond adequately to initial treatments. Recent evidence shows that ketamine administered to patients with treatment resistant depression has resulted in marked improvement within hours of treatment. Boehringer Ingelheim (the Seeker) desires a working hypothesis for ketamine’s mechanism of action and sustained antidepressant effect. The submitted solutions will be considered for the award. There will be a guaranteed award for at least one submitted solution. The total payout will be $21,000, with at least one award being no smaller than $12,000 and no award being smaller than $3,000. 2. Additional application for Research Funding In addition to consideration for the award for the submitted Solutions, Solvers with appropriate qualifications and expertise having access to a suitable research laboratory and equipment can apply for research funding (“Research Funding”) to execute a research plan that is proposed in the Solution. The requested funding should not exceed a funding period of 2 years and a total budget of $200,000. The selection of candidates for Research Funding will be conducted after completion of this Challenge, and will require the submission of additional information. The decision to fund research will be at the discretion of the Seeker.   [更多]

兰索拉唑肠溶胶囊（天津武田）处方工艺和处方用量。   [更多]

　　因公司发展需要，急需甲钴胺的大生产或中试后的生产工艺，要求能批量得到合格的产品，符合国家药品标准，步骤在两步之内，最好从VB12开始做，价格好商量，公司和个人合作都可!   [更多]

寻求常温结晶法生产高稳定性过碳酸钠 工业纯碱和双氧水加入内稳定剂，温度在15~30℃之间反应生成过碳酸钠。 目前工艺难度： (1)产品圆整度、硬度不好; (2)收率低; (3)稳定性差。急需解决。 预期达到技术、经济指标： 1、产品外观颗粒大小均匀、圆整度、硬度好。 2、稳定性等指标符合行业标准。 3、收率：碱0.72kg/kg产品，H2O2：1.2kg(27.5%)/kg产品。   [更多]

一、糠醛两步法生产工艺研究 糠醛是一种重要的化工原料，具有广阔的应用前景。目前，我公司生产糠醛主要采用一步法生产，一步法蒸汽消耗量大，一般吨醛消耗蒸汽18～25t，且该法糠醛收率最高只有6O%，原料得不到充分利用，并产生大量的废渣。随着糠醛工业的发展，以及原料综合利用要求的提高，发展两步法糠醛生产工艺，分离原料中的纤维素和半纤维素并分别加以利用，是糠醛工业的必然发展趋势，但是两步法工艺较为复杂，设备投资高，第二步脱水工艺条件不十分成熟， 因此公司希望可以与其他单位合作，共同研究糠醛两步法生产工艺，以达到提高收率，抑制生成的糠醛发生副反应，并提高原料综合利用率。 二、糠醛生产中纤维素的深度开发 1、生物基材料---糠醛生产中纤维素的深度开发; 2、二氧化硫脲漂白高岭土的应用技术; 3、二氧化硫脲在靛蓝印染上的应用 三、糠醛渣制造生物柴油深度开发研究 我公司水解釜排出来的废渣，经过锅炉烟道气流化干燥后直接进入锅炉去燃烧。锅炉燃烧所产生的烟道气经旋风除尘，湿法脱硫，硫化干燥水解废渣，最后再进入高空烟囱排放。但是由于糠醛渣含水率高，发热值低，燃烧处理时利用率较低。因此，糠醛渣深度开发、有效利用成为糠醛生产企业的一大难题。 由于生物柴油具有优良的环保特性，良好的燃料性能，并具有可再生性，开发糠醛渣制造生物柴油新技术，解决企业糠醛渣废固利用，增加效益，提升企业技术水平和经济效益。 因此公司希望可以与其他单位合作，共同研发布   [更多]

求购药品电子监管码，即药品包装上的条形码，是药品的商品条码，以下为具体要求： 1.基本包含所有国内上市药品和药品的全套信息，包括：每类药品的所有厂家，每个厂家不同的剂型和不同包装规格的条形码 2.提供格式以EXCEL电子版本格式   [更多]

合理的大生产工艺即可或中试工艺   [更多]

抑制细胞外神经信号的作用可以通过抑制受体或去除配位体来产生。我们需要一个实例或证据来证明抑制受体和损耗配体是怎么阻断信号的，比如可以变构小分子或大分子或竞争性抑制。具体看下面链接： https://www.innocentive.com/ar/challenge/9933720 AWARD: $20,000 USD | DEADLINE: 2/25/15 | ACTIVE SOLVERS: 19 | POSTED: 1/26/15 Inhibition of extracellular signaling can occur through an inhibition of a receptor or removal of a ligand. What evidence is there that one method of inhibition is more efficient or efficacious than the other at blocking signaling? The Seeker is specifically looking for well-supported examples of receptor/ligand inhibition where both methods of inhibition exist. This Challenge requires only a written proposal. Source: InnoCentive Challenge ID: 9933720 Challenge Overview Inhibition of extracellular neuronal signaling can occur through the inhibition of a receptor or removal of a ligand. What evidence is there (or lack of) that one method of inhibition (inhibition of the receptor versus depletion of the ligand) is more efficient or efficacious than the other at blocking signaling? Inhibition can be allosteric or competitive, small molecule or large molecule. The Seeker is specifically looking for well-supported examples of receptor/ligand inhibition where both methods of inhibition exist. Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on February 25, 2015. Late submissions will not be considered.   [更多]

我公司拟生产如下产品：医用棉签，医用薄膜手套，医用绷带，医用棉球，一次性口罩，一次性帽子，一次性使用止血带，一次性使用引流袋，一次性使用负压引流袋，液体敷料，医用冷敷贴。 如有全套备案资料者请联系。   [更多]

实单求购伐昔洛韦杂质N 10mg/20mg/100mg 能提供的请联系17621899918   [更多]