What Disruptive Innovations Does Pharma Need To Discover Tomorrow’s Drugs?
AWARD: $5,000 USD | DEADLINE: 10/15/12 | ACTIVE SOLVERS: 220 | POSTED: 9/14/12 Source: InnoCentive Challenge ID: 9932826 Type: Ideation
Detailed Description & Requirements
Productivity in drug discovery & development – the number of new drugs reaching patients – has been declining. At the same time, R&D spending has been increasing. Industry experts calculate the mean R&D spend per new drug on the market is $4-11 billion dollars.
2012 Forbes Article: The Truly Staggering Cost of Inventing New Drugs
Various factors contribute to this high development cost. The most prominent is the high rate of attrition (failure) on drug like compounds as they pass through the drug development process. For every 10,000 compounds that appear interesting during basic research, 1 may reach market as an approved drug.
Causes of compounds not progressing include:
Lack of efficacy or potency
Toxicity or safety
Increasing regulatory stringency in approving drugs for clinical trial and for market
Increasing emphasis on stratification of patient populations for administration of drugs (personalized medicine)
Factors contributing to these causes include, but are not limited to:
Assay systems and platforms that poorly replicate drug effects in humans
Lack of new therapeutic drug targets being identified e.g. phenotypic screening data is difficult to convert into new molecular targets
Animal experimental data, too, poorly predicts effects in humans / translational medicine
Lack of good validated biomarkers to measure disease states or predict [更多]