njruich 2012-11-20 17:22
需要意大利药典标准的匹多莫德口服溶液的标准,不是欧洲药典的,如果有请报价   [更多]
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changxin 2012-11-12 14:29
什么样的顺序和结构性因素会影响小肽服用后的生物利用度? 哪些生理数据能确定肽被服用后是否进入到全身血液循环? 哪些模型能够用于评估肽的生物利用度? 这项任务是要求从相关的出版物,硅片模型和现有的研究数据中总结出有建设性的结论,提交一份书面建议书。 “征稿件请直接上传网址:https://www.innocentive.com” Understanding Bioavailability of Peptides TAGS: Nature, Global Health, Life Sciences, Food/Agriculture, Chemistry, Theoretical-licensing AWARD: $20,000 USD | DEADLINE: 1/09/13 | ACTIVE SOLVERS: 35 | POSTED: 11/09/12 What sequence and structural factors influence the bioavailability of small peptides following ingestion? Which physiological parameters determine whether peptides reach and persist in the systemic circulation, and which models would be relevant to assess peptide bioavailability? The Seeker is looking for insightful submissions that are supported by peer-reviewed publications, in-silico modelling &/or existing research data. This Challenge requires only a written proposal. Detailed Description & Requirements Background Hydrolysed milk proteins are used both in infant feeds and other food products. Either heat and pH or enzymatic processes are used to hydrolyze whey or casein proteins to smaller peptide species or single amino acids. These preparations contain peptides of 2-12 amino acids in length. While the mechanisms by which individual amino acids are absorbed and metabolized is well understood the knowledge about absorption mechanisms of peptides is much more limited. This Challenge requests in depth theoretical insights regarding which amino acid sequences or structures of casein-derived peptides and which physiological parameters are most influential in determining bioavailability. The focus is on bioavailability in human infants (0-2 years). Problem Bovine casein is a mix of AlphaS1, AlphaS2, Beta and Kappa-casein. Extensively hydrolysed casein contains a mixture of peptides 2-12 amino acids in length. Besides their established application in cow’s milk allergy, these casein hydrolysate derived peptides may   [更多]
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lixiang 2012-11-08 14:49
求购5-硝基糠醛二乙酯合成工艺,要求收率超过80%,勿复制粘贴网上内容,有意者可寻求合作   [更多]
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06070013 2012-11-07 11:49
求购三黄片中黄芩浸膏的制备工艺 应按照2010版药典中三黄片质量标准项下要求工艺进行,并符合其质量标准。   [更多]
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heyue9325 2012-11-05 17:17
连翘叶提取物要求:水分:4%以下,连翘苷含量:5.0%以上,3%的连翘叶提取物水溶液灯光下观察澄清透明,能过0.45的微膜。   [更多]
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changxin 2012-11-02 11:57
PXE国际关于弹性假黄瘤(PXE)的研究团队,对其的病因提出了现有的两种假设:积极的循环代谢产物或者组织特异性功能障碍。任务要求提供数据来求证这两种假设或其中之一。根据各地的发病机制进行实验,进一步了解PXE的病因。 这项任务保证至少会奖励一名挑战者,并且,除了任务奖金之外,PXE国际还将对中标者给予PXE的研究经费资助。 征稿件请直接上传网址:https://www.innocentive.com PXE – Evaluating Hypotheses and Suggesting Experiments for a Rare Disease TAGS: Computer Science/Information Technology, Chemistry, Global Health, Nature, Public Good, Life Sciences, Ideation AWARD: $7,000 USD | DEADLINE: 11/30/12 | ACTIVE SOLVERS: 38 | POSTED: 10/31/12 The Seeker, PXE International, the primary group responsible for funding PXE research, presents two existing hypotheses (an active circulating metabolite(s) or a tissue-specific dysfunction) for the rare disease Pseudoxanthoma Elasticum (PXE). The Seeker requests that Solvers present evidence favoring one of the two hypotheses, then provide additional experiments to conduct to further knowledge around the disease mechanism. This is an Ideation Challenge with a guaranteed award for at least one submitted solution. In addition to the Challenge award, PXE International will also assist finalists in efforts to obtain funding for PXE-related research. Detailed Description & Requirements INTRODUCTION TO PXE Pseudoxanthoma Elasticum (PXE) is a recessive genetic disorder with signs and symptoms that mimic many aspects of the normal aging process, but at a much younger age (when people are roughly between 10 and 20 years old). Specifically, the disease is characterized by fragmentation and mineralization of elastic fibers in certain tissues. Some of the more common symptoms, in general order that they occur, are: Wet-type macular degeneration Skin wrinkling Calcification of blood vessels Cardiovascular disease PXE is a rare disease with an estimated patient population of 12,000 people. Given the small number of people with the disease, it has not been the subject of research by for-profit pharmaceutical and biotech companies.   [更多]
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dushi 2012-11-01 17:23
求购英国药典2012的“注射用盐酸多巴胺”标准,必须要完全符合以下所有标准,不符条件请勿投标, 1. 只要英国药典2012版本的,其他版本的不要 根据BP2012索引显示,在 第2755页 2.是“dopamine hydrochloride for injection”(注射用盐酸多巴胺),而不是dopamine hydrochloride injection(盐酸多巴胺注射液) 符合条件的请直接上传附件,在符合要求的前提下,先投标并上传附件都中标。   [更多]
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yuheng 2012-11-01 12:03
 我单位现在是这样的情况:新建的车间但是缺少能生产的项目(化工合成原料药或中间体)。希望找到一个可以合作伙伴给提供项目   [更多]
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alexwu1983 2012-10-25 13:51
雷贝拉唑钠小试工艺和少量合格样品,原料药合成的   [更多]
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史克 2012-10-21 23:10
1975年美国史克公司成功研制合成新一代寄生虫克星:阿苯达唑。现在阿苯达唑已在法国、非洲、拉丁美洲及中东等70多个国家应用于临床;使用患者超过4亿人次。 为了更好的把握未来,我们需要一些肠胃健康类产品, 如果您拥有一项肠胃健康类产品相关的创新配方、技术、产品、包装方法、陈列设计,甚至是最富创意的商业模式,能够积极改善消费者的生活;如果您拥有适合中美史克现有产品、品牌的商业机会,愿意与中美史克创新发展中心共同分享;中美史克真诚的欢迎阁下的创新方案,愿与您共同讨论、合作,并将您的创新方案变为现实! 联系方式 中美史克张先生 (Eric Zhang) 新产品引进创新经理 电话:86-10-59252649 传真:86-10-59252904 E-mail: oax74532@gsk.com   [更多]
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